| pubmed-article:15684084 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15684084 | lifeskim:mentions | umls-concept:C0009319 | lld:lifeskim |
| pubmed-article:15684084 | lifeskim:mentions | umls-concept:C0025474 | lld:lifeskim |
| pubmed-article:15684084 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:15684084 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15684084 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:15684084 | lifeskim:mentions | umls-concept:C0080202 | lld:lifeskim |
| pubmed-article:15684084 | lifeskim:mentions | umls-concept:C2362651 | lld:lifeskim |
| pubmed-article:15684084 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:15684084 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:15684084 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15684084 | pubmed:dateCreated | 2005-2-9 | lld:pubmed |
| pubmed-article:15684084 | pubmed:abstractText | Inflammatory bowel disease reflects an aberrant mucosal CD4+ T cell response to commensal enteric bacteria. In addition to regulatory T cell subsets, recent studies have revealed a protective role of B cells in murine CD4+ T cell colitis, but the relationship of their action to T cell immunoregulation is unknown. Here we report that mesenteric lymph node (MLN) B cells protect mice from colitis induced by Galphai2-/- CD4+ T cells. Protection required the transfer of both B cells and CD8alpha+ T cells; neither cell type alone was sufficient to inhibit CD4+ T cell-mediated colitis. Similar results were also observed in colitis induced by CD4+CD45RBhi T cells. Immunoregulation was associated with localization of B cells and expansion of CD4-CD8- CD3+NK1.1+ T cells in the secondary lymphoid compartment, as well as expansion of CD4+CD8alpha+ T cells in the intestinal intraepithelial compartment. MLN B cells from Galphai2-/- mice were deficient in a phenotypic subset and failed to provide cotransfer colitis protection. These findings indicate that protective action of B cells is a selective trait of MLN B cells acquired through a Galphai2-dependent developmental process and link B cells with the formation of regulatory T cells associated with mucosal immune homeostasis. | lld:pubmed |
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| pubmed-article:15684084 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15684084 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15684084 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15684084 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15684084 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:15684084 | pubmed:author | pubmed-author:KUY CYC | lld:pubmed |
| pubmed-article:15684084 | pubmed:author | pubmed-author:BirnbaumerLut... | lld:pubmed |
| pubmed-article:15684084 | pubmed:author | pubmed-author:BraunJonathan... | lld:pubmed |
| pubmed-article:15684084 | pubmed:author | pubmed-author:ArandaRichard... | lld:pubmed |
| pubmed-article:15684084 | pubmed:author | pubmed-author:KronenbergMit... | lld:pubmed |
| pubmed-article:15684084 | pubmed:author | pubmed-author:TurovskayaOlg... | lld:pubmed |
| pubmed-article:15684084 | pubmed:author | pubmed-author:VelazquezPete... | lld:pubmed |
| pubmed-article:15684084 | pubmed:author | pubmed-author:SpricherKarst... | lld:pubmed |
| pubmed-article:15684084 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15684084 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:15684084 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:15684084 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15684084 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15684084 | pubmed:pagination | 2010-5 | lld:pubmed |
| pubmed-article:15684084 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15684084 | pubmed:meshHeading | pubmed-meshheading:15684084... | lld:pubmed |
| pubmed-article:15684084 | pubmed:meshHeading | pubmed-meshheading:15684084... | lld:pubmed |
