Linked Life Data

15671568

Source:http://linkedlifedata.com/resource/pubmed/id/15671568

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15671568rdf:typepubmed:Citationlld:pubmed
pubmed-article:15671568lifeskim:mentionsumls-concept:C0020971lld:lifeskim
pubmed-article:15671568lifeskim:mentionsumls-concept:C0027651lld:lifeskim
pubmed-article:15671568lifeskim:mentionsumls-concept:C0026336lld:lifeskim
pubmed-article:15671568lifeskim:mentionsumls-concept:C1332717lld:lifeskim
pubmed-article:15671568lifeskim:mentionsumls-concept:C1706438lld:lifeskim
pubmed-article:15671568lifeskim:mentionsumls-concept:C0079731lld:lifeskim
pubmed-article:15671568lifeskim:mentionsumls-concept:C0085358lld:lifeskim
pubmed-article:15671568lifeskim:mentionsumls-concept:C0012854lld:lifeskim
pubmed-article:15671568lifeskim:mentionsumls-concept:C0054946lld:lifeskim
pubmed-article:15671568lifeskim:mentionsumls-concept:C0020964lld:lifeskim
pubmed-article:15671568lifeskim:mentionsumls-concept:C1417326lld:lifeskim
pubmed-article:15671568lifeskim:mentionsumls-concept:C1413244lld:lifeskim
pubmed-article:15671568lifeskim:mentionsumls-concept:C2698600lld:lifeskim
pubmed-article:15671568lifeskim:mentionsumls-concept:C1706319lld:lifeskim
pubmed-article:15671568lifeskim:mentionsumls-concept:C0805586lld:lifeskim
pubmed-article:15671568pubmed:issue1lld:pubmed
pubmed-article:15671568pubmed:dateCreated2005-1-26lld:pubmed
pubmed-article:15671568pubmed:abstractTextThe CD20 B-cell differentiation antigen is an attractive target for immunotherapy of B-cell lymphomas. In an experimental lymphoma model, BALB/c mice were immunized with mouse or human CD20 cDNA (mCD20 and hCD20, respectively) or their extracellular domains (minigenes). IFNgamma secretion by CD8+ T cells against CD20 was detected in mice vaccinated with hCD20 or human minigene, indicating that hCD20-primed CD8+ T cells recognize syngeneic CD20. Systemic challenge with syngeneic A20 cells, an aggressive lymphoma, resulted in long-term survival in a subset of immunized mice. Overall long-term survival was 14% in groups vaccinated with the human minigene versus 4% in control groups (P < 0.001). CD8+ T-cell depletion during the effector phase completely abrogated this effect. Antibodies against a recombinant mouse CD20 protein produced in insect cells were detected in mice immunized with hCD20 DNA and human and mouse minigene, but not in mice receiving mCD20 DNA. These results show that active immunization with xenogeneic DNA vaccines can induce CD8+ T cell-dependent immunity against CD20.lld:pubmed
pubmed-article:15671568pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15671568pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15671568pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15671568pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15671568pubmed:languageenglld:pubmed
pubmed-article:15671568pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15671568pubmed:citationSubsetIMlld:pubmed
pubmed-article:15671568pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15671568pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15671568pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15671568pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15671568pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15671568pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15671568pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15671568pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15671568pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15671568pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15671568pubmed:statusMEDLINElld:pubmed
pubmed-article:15671568pubmed:monthJanlld:pubmed
pubmed-article:15671568pubmed:issn1078-0432lld:pubmed
pubmed-article:15671568pubmed:authorpubmed-author:YeoI JIJlld:pubmed
pubmed-article:15671568pubmed:authorpubmed-author:HoughtonAlan...lld:pubmed
pubmed-article:15671568pubmed:authorpubmed-author:WolchokJedd...lld:pubmed
pubmed-article:15671568pubmed:authorpubmed-author:ScheinbergDav...lld:pubmed
pubmed-article:15671568pubmed:authorpubmed-author:RobertsWendy...lld:pubmed
pubmed-article:15671568pubmed:authorpubmed-author:Guevara-Patiñ...lld:pubmed
pubmed-article:15671568pubmed:authorpubmed-author:PalombaMaria...lld:pubmed
pubmed-article:15671568pubmed:authorpubmed-author:ManukianGrego...lld:pubmed
pubmed-article:15671568pubmed:issnTypePrintlld:pubmed
pubmed-article:15671568pubmed:day1lld:pubmed
pubmed-article:15671568pubmed:volume11lld:pubmed
pubmed-article:15671568pubmed:ownerNLMlld:pubmed
pubmed-article:15671568pubmed:authorsCompleteYlld:pubmed
pubmed-article:15671568pubmed:pagination370-9lld:pubmed
pubmed-article:15671568pubmed:dateRevised2008-11-21lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:meshHeadingpubmed-meshheading:15671568...lld:pubmed
pubmed-article:15671568pubmed:year2005lld:pubmed
pubmed-article:15671568pubmed:articleTitleCD8+ T-cell-dependent immunity following xenogeneic DNA immunization against CD20 in a tumor challenge model of B-cell lymphoma.lld:pubmed
pubmed-article:15671568pubmed:affiliationDepartment of Medicine and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. palombam@mskcc.orglld:pubmed
pubmed-article:15671568pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15671568pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:15671568pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:15671568pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed