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pubmed-article:15667552pubmed:abstractTextEight cellular homologs of the inhibitors-of-apoptosis proteins (IAP) have been identified in humans and of them, the X-linked IAP (XIAP) is the most potent. XIAP-associated factor 1 (XAF1) is a newly discovered XIAP-binding protein that negatively regulates the caspase-inhibiting activity of XIAP. It is either not expressed or present at extremely low levels in many cancer cell lines. The aims of the present study were: (i) to investigate the expression of XAF1 in human colorectal cancers (CRC) both in vitro and in vivo, and (ii) to evaluate the possibility of XAF1 as a new tumor marker.lld:pubmed
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pubmed-article:15667552pubmed:authorpubmed-author:ZhongJieJlld:pubmed
pubmed-article:15667552pubmed:authorpubmed-author:JiangShi HuSHlld:pubmed
pubmed-article:15667552pubmed:authorpubmed-author:MaTian LeTLlld:pubmed
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pubmed-article:15667552pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:15667552pubmed:articleTitleLow expression of XIAP-associated factor 1 in human colorectal cancers.lld:pubmed
pubmed-article:15667552pubmed:affiliationDepartment of Gastroenterology, Ruijin Hospital, Shanghai Second Medical University, Shanghai, China. mtla@etang.comlld:pubmed
pubmed-article:15667552pubmed:publicationTypeJournal Articlelld:pubmed
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