| pubmed-article:15661872 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15661872 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15661872 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:15661872 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:15661872 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:15661872 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:15661872 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15661872 | pubmed:dateCreated | 2005-1-21 | lld:pubmed |
| pubmed-article:15661872 | pubmed:abstractText | TCR/CD3 complex-mediated signals play critical roles in regulating CD4(+) Th cell differentiation. In this report, we have examined the in vivo role of a key TCR/CD3 complex molecule zeta-chain in regulating the differentiation of Th cells. We have studied T cells from zeta-chain-deficient mice (zetaKO mice), zeta-chain-bearing mice (zeta(+) mice), and from zetaKO mice expressing a FcRgamma chain transgene (FcRgammaTG, zetaKO mice). Our results demonstrated that, compared with those of control mice, CD4(+) T cells and not CD8(+) T cells from zetaKO mice were polarized into IFN-gamma-producing cells. Some of these IFN-gamma-producing cells could also secrete IL-10. Interestingly, zetaKO mouse T cells produced IFN-gamma even after they were cultured in a Th2 condition. Our studies to determine the molecular mechanisms underlying the polarized IFN-gamma production revealed that the expression level of STAT4 and T-bet were up-regulated in freshly isolated T cells from zetaKO mice. Further studies showed that noncultured zetaKO mice CD4(+) T cells and thymocytes bore a unique memory cell-like CD44(high), CD62L(low/neg) phenotype. Altogether, these results suggest that, in the absence of the zeta-chain, CD4(+) T cells develop as polarized IFN-gamma-producing cells that bear a memory cell-like phenotype. The zeta-chain-bearing T cells may produce a large amount of IFN-gamma only after they are cultured in a condition favoring Th1 cell differentiation. This study may provide important implications for the down-regulation of zeta-chain in T cells of patients bearing a variety of tumors, chronic inflammatory and infectious diseases. | lld:pubmed |
| pubmed-article:15661872 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15661872 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661872 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15661872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15661872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15661872 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15661872 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15661872 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:15661872 | pubmed:author | pubmed-author:LeeWen-HuiWH | lld:pubmed |
| pubmed-article:15661872 | pubmed:author | pubmed-author:LiuChih-PinCP | lld:pubmed |
| pubmed-article:15661872 | pubmed:author | pubmed-author:KrymskayaLudm... | lld:pubmed |
| pubmed-article:15661872 | pubmed:author | pubmed-author:ZhongLingwenL | lld:pubmed |
| pubmed-article:15661872 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15661872 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15661872 | pubmed:volume | 174 | lld:pubmed |
| pubmed-article:15661872 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15661872 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15661872 | pubmed:pagination | 1188-95 | lld:pubmed |
| pubmed-article:15661872 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15661872 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15661872 | pubmed:articleTitle | Polarized development of memory cell-like IFN-gamma-producing cells in the absence of TCR zeta-chain. | lld:pubmed |
| pubmed-article:15661872 | pubmed:affiliation | Division of Immunology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA. | lld:pubmed |
| pubmed-article:15661872 | pubmed:publicationType | Journal Article | lld:pubmed |
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