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pubmed-article:15661263pubmed:abstractTextWe investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of IFITM1 was found significantly different between the high- and low-risk groups (P = 9.7976 x 10(-11)) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher IFITM1 expression correlated with improved survival (P = 0.01). These results indicate that IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival.lld:pubmed
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pubmed-article:15661263pubmed:articleTitleExpression of IFITM1 in chronic myeloid leukemia patients.lld:pubmed
pubmed-article:15661263pubmed:affiliationDepartment of Molecular Biology and Genetics, Bilkent University, Bilkent, 06800 Ankara, Turkey.lld:pubmed
pubmed-article:15661263pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15661263pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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