| pubmed-article:1565633 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1565633 | lifeskim:mentions | umls-concept:C0042216 | lld:lifeskim |
| pubmed-article:1565633 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:1565633 | lifeskim:mentions | umls-concept:C0025932 | lld:lifeskim |
| pubmed-article:1565633 | lifeskim:mentions | umls-concept:C1514798 | lld:lifeskim |
| pubmed-article:1565633 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:1565633 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:1565633 | lifeskim:mentions | umls-concept:C0162768 | lld:lifeskim |
| pubmed-article:1565633 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:1565633 | pubmed:dateCreated | 1992-5-15 | lld:pubmed |
| pubmed-article:1565633 | pubmed:abstractText | We have developed a method for attenuating vaccinia virus recombinants by expressing a fusion protein of a lymphokine and an immunogen. Chimeric genes were constructed that coded for gamma interferon (IFN-gamma) and structural proteins of the human immunodeficiency virus type 1 (HIV-1). In this study, we describe the biological and immunological properties of vaccinia virus recombinants expressing chimeric genes of murine or human IFN-gamma with glycoprotein gp120, gag, and a fragment of gp41. All fusion proteins retained the antigenic characteristics of both IFN-gamma and HIV as shown by immunoblot analysis. However, the antiviral activity of IFN-gamma could be demonstrated only for the IFN-gamma-gag fusion protein. In contrast, the attenuating activity of IFN-gamma for nude mice was retained by all of the recombinants, albeit at various rates. Unlike the antiviral activity, the attenuating activity of IFN-gamma was not species specific. Implications for the development of attenuated live recombinant vaccines for AIDS are discussed. | lld:pubmed |
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| pubmed-article:1565633 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1565633 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1565633 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1565633 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1565633 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1565633 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1565633 | pubmed:author | pubmed-author:NgC TCT | lld:pubmed |
| pubmed-article:1565633 | pubmed:author | pubmed-author:GibsonH LHL | lld:pubmed |
| pubmed-article:1565633 | pubmed:author | pubmed-author:GardnerM BMB | lld:pubmed |
| pubmed-article:1565633 | pubmed:author | pubmed-author:YilmaTT | lld:pubmed |
| pubmed-article:1565633 | pubmed:author | pubmed-author:JonesLL | lld:pubmed |
| pubmed-article:1565633 | pubmed:author | pubmed-author:BarrP JPJ | lld:pubmed |
| pubmed-article:1565633 | pubmed:author | pubmed-author:GiavedoniL... | lld:pubmed |
| pubmed-article:1565633 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1565633 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1565633 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:1565633 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1565633 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1565633 | pubmed:pagination | 3409-13 | lld:pubmed |
| pubmed-article:1565633 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1565633 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1565633 | pubmed:articleTitle | Vaccinia virus recombinants expressing chimeric proteins of human immunodeficiency virus and gamma interferon are attenuated for nude mice. | lld:pubmed |
| pubmed-article:1565633 | pubmed:affiliation | Department of Veterinary Microbiology and Immunology, University of California, Davis 95616. | lld:pubmed |
| pubmed-article:1565633 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1565633 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1565633 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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