| pubmed-article:15647482 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15647482 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:15647482 | lifeskim:mentions | umls-concept:C0205384 | lld:lifeskim |
| pubmed-article:15647482 | lifeskim:mentions | umls-concept:C1622525 | lld:lifeskim |
| pubmed-article:15647482 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:15647482 | lifeskim:mentions | umls-concept:C1414477 | lld:lifeskim |
| pubmed-article:15647482 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15647482 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:15647482 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:15647482 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15647482 | pubmed:dateCreated | 2005-1-13 | lld:pubmed |
| pubmed-article:15647482 | pubmed:abstractText | We investigated how the neural cell adhesion molecule L1 mediates neurite outgrowth through L1-L1 homophilic interactions. Wild-type L1 and L1 with mutations in the cytoplasmic domain (CD) were introduced into L1 knock-out neurons, and transfected neurons were grown on an L1 substrate. Neurite length and branching were compared between wild-type L1 and L1CD mutations. Surprisingly, the L1CD is not required for L1-mediated neurite outgrowth but plays a critical role in neurite branching, through both the juxtamembrane region and the RSLE region. We demonstrate that both regions serve as ezrin-moesin-radixin-binding sites. A truncation mutant that deletes 110 of 114 amino acids of the L1CD still supports neurite outgrowth on an L1 substrate, suggesting that a coreceptor binds to L1 in cis and mediates neurite outgrowth and that L1-ankyrin interactions are not essential for neurite initiation or outgrowth. These data are consistent with a model in which L1 can influence L1-mediated neurite outgrowth and branching through both the L1CD and a coreceptor. | lld:pubmed |
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| pubmed-article:15647482 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15647482 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15647482 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15647482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15647482 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15647482 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15647482 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:15647482 | pubmed:author | pubmed-author:ItohKouichiK | lld:pubmed |
| pubmed-article:15647482 | pubmed:author | pubmed-author:LemmonVanceV | lld:pubmed |
| pubmed-article:15647482 | pubmed:author | pubmed-author:ChengLingL | lld:pubmed |
| pubmed-article:15647482 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15647482 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:15647482 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:15647482 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15647482 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15647482 | pubmed:pagination | 395-403 | lld:pubmed |
| pubmed-article:15647482 | pubmed:dateRevised | 2011-4-1 | lld:pubmed |
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