| pubmed-article:15637112 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15637112 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15637112 | lifeskim:mentions | umls-concept:C0003842 | lld:lifeskim |
| pubmed-article:15637112 | lifeskim:mentions | umls-concept:C0012359 | lld:lifeskim |
| pubmed-article:15637112 | lifeskim:mentions | umls-concept:C0038836 | lld:lifeskim |
| pubmed-article:15637112 | lifeskim:mentions | umls-concept:C0205216 | lld:lifeskim |
| pubmed-article:15637112 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:15637112 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:15637112 | lifeskim:mentions | umls-concept:C0181586 | lld:lifeskim |
| pubmed-article:15637112 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15637112 | pubmed:dateCreated | 2005-4-20 | lld:pubmed |
| pubmed-article:15637112 | pubmed:abstractText | The role of mitochondrial manganese-superoxide dismutase (Mn-SOD) in the maintenance of vascular function has not yet been studied. Thus we examined flow- and agonist-induced dilations in isolated mesenteric arteries (approximately 90 microm in diameter) of Mn-SOD heterozygous (Mn-SOD+/-) and wild-type (WT) mice. Increases in flow elicited dilations in all vessels, but the magnitude of the dilation was significantly less in vessels of Mn-SOD+/- mice than in those of WT mice (64 vs. 74% of passive diameter). N(omega)-nitro-L-arginine methyl ester inhibited the dilation in vessels of WT mice but had no effect on vessels of Mn-SOD+/- mice. Tempol or tiron (superoxide scavengers) increased flow-induced dilation in vessels of Mn-SOD+/- mice. Acetylcholine- and sodium nitroprusside-induced, but not adenosine-induced, dilations were also decreased in arteries of Mn-SOD+/- mice. Superoxide levels in the arteries of Mn-SOD+/- mice were significantly increased. Western blot analysis confirmed a 50% reduction of Mn-SOD protein in the vessels of Mn-SOD+/- mice. A 41% reduction in endothelial nitric oxide synthase (eNOS) protein and a 37% reduction in eNOS activity were also found in the vessels of Mn-SOD+/- mice. Whereas there was no difference in eNOS protein in kidney homogenates of WT and Mn-SOD+/- mice, a significant reduction of nitric oxide synthase activity was found in Mn-SOD+/- mice, which could be restored by the administration of tiron. We conclude that an increased concentration of superoxide due to reduced activity of Mn-SOD, which inactivates nitric oxide and inhibits eNOS activity, contributes to the impaired vasodilator function of isolated mesenteric arteries of Mn-SOD+/- mice. These results suggest that Mn-SOD contributes significantly to the regulation of vascular function. | lld:pubmed |
| pubmed-article:15637112 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637112 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637112 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637112 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637112 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637112 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637112 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637112 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15637112 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637112 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15637112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15637112 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15637112 | pubmed:month | May | lld:pubmed |
| pubmed-article:15637112 | pubmed:issn | 0363-6135 | lld:pubmed |
| pubmed-article:15637112 | pubmed:author | pubmed-author:HintzeThomas... | lld:pubmed |
| pubmed-article:15637112 | pubmed:author | pubmed-author:SunDongD | lld:pubmed |
| pubmed-article:15637112 | pubmed:author | pubmed-author:HuangAnA | lld:pubmed |
| pubmed-article:15637112 | pubmed:author | pubmed-author:KaleyGaborG | lld:pubmed |
| pubmed-article:15637112 | pubmed:author | pubmed-author:WolinMichael... | lld:pubmed |
| pubmed-article:15637112 | pubmed:author | pubmed-author:KaminskiPawel... | lld:pubmed |
| pubmed-article:15637112 | pubmed:author | pubmed-author:WuZhipingZ | lld:pubmed |
| pubmed-article:15637112 | pubmed:author | pubmed-author:YanChangdongC | lld:pubmed |
| pubmed-article:15637112 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15637112 | pubmed:volume | 288 | lld:pubmed |
| pubmed-article:15637112 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15637112 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15637112 | pubmed:pagination | H2225-31 | lld:pubmed |
| pubmed-article:15637112 | pubmed:dateRevised | 2011-11-1 | lld:pubmed |
| pubmed-article:15637112 | pubmed:meshHeading | pubmed-meshheading:15637112... | lld:pubmed |
| pubmed-article:15637112 | pubmed:meshHeading | pubmed-meshheading:15637112... | lld:pubmed |
| pubmed-article:15637112 | pubmed:meshHeading | pubmed-meshheading:15637112... | lld:pubmed |
| pubmed-article:15637112 | pubmed:meshHeading | pubmed-meshheading:15637112... | lld:pubmed |
| pubmed-article:15637112 | pubmed:meshHeading | pubmed-meshheading:15637112... | lld:pubmed |
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| pubmed-article:15637112 | pubmed:meshHeading | pubmed-meshheading:15637112... | lld:pubmed |
| pubmed-article:15637112 | pubmed:meshHeading | pubmed-meshheading:15637112... | lld:pubmed |
| pubmed-article:15637112 | pubmed:meshHeading | pubmed-meshheading:15637112... | lld:pubmed |
| pubmed-article:15637112 | pubmed:meshHeading | pubmed-meshheading:15637112... | lld:pubmed |
| pubmed-article:15637112 | pubmed:meshHeading | pubmed-meshheading:15637112... | lld:pubmed |
| pubmed-article:15637112 | pubmed:meshHeading | pubmed-meshheading:15637112... | lld:pubmed |
| pubmed-article:15637112 | pubmed:meshHeading | pubmed-meshheading:15637112... | lld:pubmed |
| pubmed-article:15637112 | pubmed:meshHeading | pubmed-meshheading:15637112... | lld:pubmed |
| pubmed-article:15637112 | pubmed:meshHeading | pubmed-meshheading:15637112... | lld:pubmed |
| pubmed-article:15637112 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15637112 | pubmed:articleTitle | Increased superoxide leads to decreased flow-induced dilation in resistance arteries of Mn-SOD-deficient mice. | lld:pubmed |
| pubmed-article:15637112 | pubmed:affiliation | Deptartment of Physiology, New York Medical College, Valhalla, New York 10595, USA. | lld:pubmed |
| pubmed-article:15637112 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15637112 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:20656 | entrezgene:pubmed | pubmed-article:15637112 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15637112 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15637112 | lld:pubmed |
