| pubmed-article:15634895 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15634895 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15634895 | lifeskim:mentions | umls-concept:C0018956 | lld:lifeskim |
| pubmed-article:15634895 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15634895 | pubmed:dateCreated | 2005-1-6 | lld:pubmed |
| pubmed-article:15634895 | pubmed:abstractText | Whereas multiple growth-promoting cytokines have been demonstrated to be involved in regulation of the hemopoietic stem cell (HSC) pool, the potential role of negative regulators is less clear. However, IFN-gamma, if overexpressed, can mediate bone marrow suppression and has been directly implicated in a number of bone marrow failure syndromes, including graft-vs-host disease. Whether IFN-gamma might directly affect the function of repopulating HSCs has, however, not been investigated. In the present study, we used in vitro conditions promoting self-renewing divisions of human HSCs to investigate the effect of IFN-gamma on HSC maintenance and function. Although purified cord blood CD34(+)CD38(-) cells underwent cell divisions in the presence of IFN-gamma, cycling HSCs exposed to IFN-gamma in vitro were severely compromised in their ability to reconstitute long-term cultures in vitro and multilineage engraft NOD-SCID mice in vivo (>90% reduced activity in both HSC assays). In vitro studies suggested that IFN-gamma accelerated differentiation of targeted human stem and progenitor cells. These results demonstrate that IFN-gamma can negatively affect human HSC self-renewal. | lld:pubmed |
| pubmed-article:15634895 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15634895 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15634895 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15634895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15634895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15634895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15634895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15634895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15634895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15634895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15634895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15634895 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15634895 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15634895 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15634895 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:15634895 | pubmed:author | pubmed-author:SasakiYutakaY | lld:pubmed |
| pubmed-article:15634895 | pubmed:author | pubmed-author:NilssonLarsL | lld:pubmed |
| pubmed-article:15634895 | pubmed:author | pubmed-author:BryderDavidD | lld:pubmed |
| pubmed-article:15634895 | pubmed:author | pubmed-author:SitnickaEwaE | lld:pubmed |
| pubmed-article:15634895 | pubmed:author | pubmed-author:JacobsenSten... | lld:pubmed |
| pubmed-article:15634895 | pubmed:author | pubmed-author:YangLipingL | lld:pubmed |
| pubmed-article:15634895 | pubmed:author | pubmed-author:DybedalIngunn... | lld:pubmed |
| pubmed-article:15634895 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15634895 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15634895 | pubmed:volume | 174 | lld:pubmed |
| pubmed-article:15634895 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15634895 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15634895 | pubmed:pagination | 752-7 | lld:pubmed |
| pubmed-article:15634895 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15634895 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15634895 | pubmed:articleTitle | IFN-gamma negatively modulates self-renewal of repopulating human hemopoietic stem cells. | lld:pubmed |
| pubmed-article:15634895 | pubmed:affiliation | Hemopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden. | lld:pubmed |
| pubmed-article:15634895 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15634895 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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