| pubmed-article:15630140 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15630140 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15630140 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:15630140 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:15630140 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:15630140 | lifeskim:mentions | umls-concept:C0439836 | lld:lifeskim |
| pubmed-article:15630140 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:15630140 | lifeskim:mentions | umls-concept:C2698594 | lld:lifeskim |
| pubmed-article:15630140 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15630140 | pubmed:dateCreated | 2005-1-4 | lld:pubmed |
| pubmed-article:15630140 | pubmed:abstractText | The CD4+ CD25+ regulatory T cells play a critical role in controlling autoimmunity, but little is known about their development and maintenance. In this study, we investigated whether CD4+ CD25- cells can convert to CD4+ CD25+ regulatory T cells in vivo under natural conditions. CD4+ CD25- cells from CD45.1+ mice were sorted and transferred into congenic CD45.2+ mice. Converted CD4+ CD25+ cells could be detected in lymphoid organs as early as 1 wk after transfer and by 6 wk after transfer, 5-12% of transferred CD4+ cells expressed CD25. Converted CD4+ CD25+ cells themselves failed to proliferate after stimulation, but could suppress proliferation of responder cells in vitro, and also expressed high levels of Foxp3 mRNA. In addition, CD4+ CD25- cells transferred into thymectomized congenic mice converted to CD4+ CD25+ cells that also suppressed responder cell proliferation in vitro, and expressed high levels of Foxp3 mRNA. Finally, CD4+ CD25- cells transferred into B7-/- mice failed to convert into CD4+ CD25+ cells that exhibit the regulatory phenotype. These data indicate that CD4+ CD25- cells convert into CD4+ CD25+ regulatory T cells spontaneously in vivo and suggest that this conversion process could contribute significantly to the maintenance of the peripheral CD4+ CD25+ regulatory T cell population. | lld:pubmed |
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| pubmed-article:15630140 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15630140 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15630140 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15630140 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15630140 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15630140 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:15630140 | pubmed:author | pubmed-author:KosiewiczMich... | lld:pubmed |
| pubmed-article:15630140 | pubmed:author | pubmed-author:ZhaoYuanY | lld:pubmed |
| pubmed-article:15630140 | pubmed:author | pubmed-author:AlardPascaleP | lld:pubmed |
| pubmed-article:15630140 | pubmed:author | pubmed-author:ClarkSherry... | lld:pubmed |
| pubmed-article:15630140 | pubmed:author | pubmed-author:LiangShuangS | lld:pubmed |
| pubmed-article:15630140 | pubmed:author | pubmed-author:ParnellSarahS | lld:pubmed |
| pubmed-article:15630140 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15630140 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:15630140 | pubmed:volume | 201 | lld:pubmed |
| pubmed-article:15630140 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15630140 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15630140 | pubmed:pagination | 127-37 | lld:pubmed |
| pubmed-article:15630140 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15630140 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15630140 | pubmed:articleTitle | Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus. | lld:pubmed |
| pubmed-article:15630140 | pubmed:affiliation | Department of Microbiology and Immunology, University of Louisville Health Science Center, Louisville, KY 40202, USA. | lld:pubmed |
| pubmed-article:15630140 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15630140 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15630140 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15630140 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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