| pubmed-article:15613377 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15613377 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:15613377 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15613377 | lifeskim:mentions | umls-concept:C0018497 | lld:lifeskim |
| pubmed-article:15613377 | lifeskim:mentions | umls-concept:C0015283 | lld:lifeskim |
| pubmed-article:15613377 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:15613377 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:15613377 | lifeskim:mentions | umls-concept:C0013682 | lld:lifeskim |
| pubmed-article:15613377 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:15613377 | lifeskim:mentions | umls-concept:C0301630 | lld:lifeskim |
| pubmed-article:15613377 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:15613377 | pubmed:issue | Pt 1 | lld:pubmed |
| pubmed-article:15613377 | pubmed:dateCreated | 2005-2-14 | lld:pubmed |
| pubmed-article:15613377 | pubmed:abstractText | Developmental changes in the coupling between Ca2+ entry and exocytosis were studied in mouse inner hair cells (IHCs) which, together with the afferent endings, form the primary synapse of the mammalian auditory system. Ca2+ currents (ICa) and changes in membrane capacitance (DeltaCm) were recorded using whole-cell voltage clamp from cells maintained at body temperature, using physiological (1.3 mM) extracellular Ca2+. The magnitudes of both ICa and DeltaCm increased with maturation from embryonic stages until postnatal day 6 (P6). Subsequently, ICa gradually declined to a steady level of about -100 pA from P13 while the Ca2+-induced DeltaCm remained relatively constant, indicating a developmental increase in the Ca2+ efficiency of exocytosis. Although the size of ICa changed during development, its activation properties did not, suggesting the presence of a homogeneous population of Ca2+ channels in IHCs throughout development. The Ca2+ dependence of exocytosis changed with maturation from a fourth power relation in immature cells to an approximately linear relation in mature cells. This change applies to the release of both a readily releasable pool (RRP) and a slower secondary pool of vesicles, implying a common release mechanism for these two kinetically distinct pools that becomes modified during development. The increased Ca2+ efficiency and linear Ca2+ dependence of mature IHC exocytosis, especially over the physiological range of intracellular Ca2+, could improve the high-fidelity transmission of both brief and long-lasting stimulation. These properties make the mature cell ideally suited for fine intensity discrimination over a wide dynamic range. | lld:pubmed |
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| pubmed-article:15613377 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15613377 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15613377 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15613377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15613377 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15613377 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15613377 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:15613377 | pubmed:author | pubmed-author:KrosCorné JCJ | lld:pubmed |
| pubmed-article:15613377 | pubmed:author | pubmed-author:MarcottiWalte... | lld:pubmed |
| pubmed-article:15613377 | pubmed:author | pubmed-author:JohnsonStuart... | lld:pubmed |
| pubmed-article:15613377 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15613377 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15613377 | pubmed:volume | 563 | lld:pubmed |
| pubmed-article:15613377 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15613377 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15613377 | pubmed:pagination | 177-91 | lld:pubmed |
| pubmed-article:15613377 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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