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pubmed-article:15611808pubmed:abstractTextThere are no published studies that have assessed whether adding long-acting beta 2-agonist bronchodilators and/or inhaled steroids to chronic therapy with tiotropium would provide additional clinical benefit to patients with moderate to severe chronic obstructive pulmonary disease (COPD).lld:pubmed
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pubmed-article:15611808pubmed:articleTitleThe Canadian Optimal Therapy of COPD Trial: design, organization and patient recruitment.lld:pubmed
pubmed-article:15611808pubmed:affiliationThe Ottawa Health Research Institute, University of Ottawa, Ottawa, Canada. saaron@ottawahospital.on.calld:pubmed
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