| pubmed-article:15603556 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15603556 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:15603556 | lifeskim:mentions | umls-concept:C0155626 | lld:lifeskim |
| pubmed-article:15603556 | lifeskim:mentions | umls-concept:C0009566 | lld:lifeskim |
| pubmed-article:15603556 | lifeskim:mentions | umls-concept:C0333516 | lld:lifeskim |
| pubmed-article:15603556 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:15603556 | lifeskim:mentions | umls-concept:C1522240 | lld:lifeskim |
| pubmed-article:15603556 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15603556 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15603556 | pubmed:dateCreated | 2005-3-15 | lld:pubmed |
| pubmed-article:15603556 | pubmed:abstractText | TACE [TNF-alpha (tumour necrosis factor-alpha)-converting enzyme] plays an essential role in the shedding of TNF-alpha, which could affect the outcome of AMI (acute myocardial infarction). To investigate the clinical significance of the TACE-TNF-alpha system in AMI, we examined TACE-mediated TNF-alpha synthesis in PBMCs (peripheral blood mononuclear cells), which are a possible source of TNF-alpha in AMI. Forty-one patients with AMI and 15 healthy subjects (HS) were enrolled in the present study. PBMCs were isolated from peripheral blood on day 1 and 14 after the onset of AMI. TACE and TNF-alpha mRNA levels and intracellular median fluorescence intensity were measured by real-time RT (reverse transcriptase)-PCR and flow cytometry respectively. TACE-mediated TNF-alpha production was evaluated in cultured PBMCs with PMA, which is known to activate TACE. Spontaneous TACE and TNF-alpha levels were higher in AMI patients than in HS (P<0.001). TACE and TNF-alpha levels in PMA-stimulated PMBCs were markedly increased in AMI patients compared with HS (P<0.001). There was a positive correlation between TACE and TNF-alpha levels in AMI. Although spontaneous and stimulated levels of TACE and TNF-alpha decreased 14 days after the onset of AMI, levels in AMI patients were higher than in HS. In AMI patients with in-hospital complications (n=15; pump failure in ten, recurrent myocardial infarction in one, malignant ventricular arrhythmia in three and cardiac death in one), spontaneous and stimulated levels of TACE and TNF-alpha were higher than in patients without complications (P<0.01). These levels were higher in AMI patients with in-hospital complications 14 days after onset. These results demonstrate that TACE-mediated TNF-alpha maturation in PBMCs may play an important role in poor outcomes from AMI, suggesting that TACE may be a potential target for the inhibition of cellular TNF-alpha production in AMI. | lld:pubmed |
| pubmed-article:15603556 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15603556 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603556 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15603556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15603556 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15603556 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15603556 | pubmed:issn | 0143-5221 | lld:pubmed |
| pubmed-article:15603556 | pubmed:author | pubmed-author:NakamuraMotoy... | lld:pubmed |
| pubmed-article:15603556 | pubmed:author | pubmed-author:SatohMamoruM | lld:pubmed |
| pubmed-article:15603556 | pubmed:author | pubmed-author:HiramoriKatsu... | lld:pubmed |
| pubmed-article:15603556 | pubmed:author | pubmed-author:AkatsuTomonar... | lld:pubmed |
| pubmed-article:15603556 | pubmed:author | pubmed-author:ShimodaYudaiY | lld:pubmed |
| pubmed-article:15603556 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15603556 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:15603556 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15603556 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15603556 | pubmed:pagination | 339-47 | lld:pubmed |
| pubmed-article:15603556 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:15603556 | pubmed:meshHeading | pubmed-meshheading:15603556... | lld:pubmed |
| pubmed-article:15603556 | pubmed:meshHeading | pubmed-meshheading:15603556... | lld:pubmed |
| pubmed-article:15603556 | pubmed:meshHeading | pubmed-meshheading:15603556... | lld:pubmed |
| pubmed-article:15603556 | pubmed:meshHeading | pubmed-meshheading:15603556... | lld:pubmed |
| pubmed-article:15603556 | pubmed:meshHeading | pubmed-meshheading:15603556... | lld:pubmed |
| pubmed-article:15603556 | pubmed:meshHeading | pubmed-meshheading:15603556... | lld:pubmed |
| pubmed-article:15603556 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15603556 | pubmed:articleTitle | Activated tumour necrosis factor-alpha shedding process is associated with in-hospital complication in patients with acute myocardial infarction. | lld:pubmed |
| pubmed-article:15603556 | pubmed:affiliation | Second Department of Internal Medicine, Iwate Medical University School of Medicine, Uchimaru 19-1, Morioka 020-8505, Iwate, Japan. | lld:pubmed |
| pubmed-article:15603556 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15603556 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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