| pubmed-article:15592418 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15592418 | lifeskim:mentions | umls-concept:C0079427 | lld:lifeskim |
| pubmed-article:15592418 | lifeskim:mentions | umls-concept:C1704938 | lld:lifeskim |
| pubmed-article:15592418 | lifeskim:mentions | umls-concept:C1333533 | lld:lifeskim |
| pubmed-article:15592418 | pubmed:issue | 7018 | lld:pubmed |
| pubmed-article:15592418 | pubmed:dateCreated | 2004-12-16 | lld:pubmed |
| pubmed-article:15592418 | pubmed:abstractText | The FBXW7/hCDC4 gene encodes a ubiquitin ligase implicated in the control of chromosome stability. Here we identify the mouse Fbxw7 gene as a p53-dependent tumour suppressor gene by using a mammalian genetic screen for p53-dependent genes involved in tumorigenesis. Radiation-induced lymphomas from p53+/- mice, but not those from p53-/- mice, show frequent loss of heterozygosity and a 10% mutation rate of the Fbxw7 gene. Fbxw7+/- mice have greater susceptibility to radiation-induced tumorigenesis, but most tumours retain and express the wild-type allele, indicating that Fbxw7 is a haploinsufficient tumour suppressor gene. Loss of Fbxw7 alters the spectrum of tumours that develop in p53 deficient mice to include a range of tumours in epithelial tissues such as the lung, liver and ovary. Mouse embryo fibroblasts from Fbxw7-deficient mice, or wild-type mouse cells expressing Fbxw7 small interfering RNA, have higher levels of Aurora-A kinase, c-Jun and Notch4, but not of cyclin E. We propose that p53-dependent loss of Fbxw7 leads to genetic instability by mechanisms that might involve the activation of Aurora-A, providing a rationale for the early occurrence of these mutations in human cancers. | lld:pubmed |
| pubmed-article:15592418 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15592418 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15592418 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15592418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15592418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15592418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15592418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15592418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15592418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15592418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15592418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15592418 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15592418 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15592418 | pubmed:issn | 1476-4687 | lld:pubmed |
| pubmed-article:15592418 | pubmed:author | pubmed-author:BalmainAllanA | lld:pubmed |
| pubmed-article:15592418 | pubmed:author | pubmed-author:DecanterChris... | lld:pubmed |
| pubmed-article:15592418 | pubmed:author | pubmed-author:COXE RER | lld:pubmed |
| pubmed-article:15592418 | pubmed:author | pubmed-author:NakayamaKeiic... | lld:pubmed |
| pubmed-article:15592418 | pubmed:author | pubmed-author:MaoJian-HuaJH | lld:pubmed |
| pubmed-article:15592418 | pubmed:author | pubmed-author:BrownKenK | lld:pubmed |
| pubmed-article:15592418 | pubmed:author | pubmed-author:Perez-LosadaJ... | lld:pubmed |
| pubmed-article:15592418 | pubmed:author | pubmed-author:BrysonSheilaS | lld:pubmed |
| pubmed-article:15592418 | pubmed:author | pubmed-author:DelrosarioRey... | lld:pubmed |
| pubmed-article:15592418 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15592418 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:15592418 | pubmed:volume | 432 | lld:pubmed |
| pubmed-article:15592418 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15592418 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15592418 | pubmed:pagination | 775-9 | lld:pubmed |
| pubmed-article:15592418 | pubmed:dateRevised | 2011-5-23 | lld:pubmed |
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| pubmed-article:15592418 | pubmed:meshHeading | pubmed-meshheading:15592418... | lld:pubmed |
| pubmed-article:15592418 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15592418 | pubmed:articleTitle | Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. | lld:pubmed |
| pubmed-article:15592418 | pubmed:affiliation | Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, California 94143, USA. | lld:pubmed |
| pubmed-article:15592418 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15592418 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15592418 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:15592418 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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