| pubmed-article:15589482 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15589482 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15589482 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:15589482 | lifeskim:mentions | umls-concept:C0009368 | lld:lifeskim |
| pubmed-article:15589482 | lifeskim:mentions | umls-concept:C0065264 | lld:lifeskim |
| pubmed-article:15589482 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15589482 | lifeskim:mentions | umls-concept:C1819461 | lld:lifeskim |
| pubmed-article:15589482 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15589482 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15589482 | pubmed:dateCreated | 2004-12-13 | lld:pubmed |
| pubmed-article:15589482 | pubmed:abstractText | Interleukin (IL)-8 plays a central role in the initiation and maintenance of inflammatory responses in the inflammatory bowel disease. The proinflammatory cytokine-mediated production of IL-8 requires activation of various kinases, which leads to the IkappaB degradation and NF-kappaB activation. In this study, we investigated the role of luteolin, a major flavonoid of Lonicera japonica, on TNF-alpha-induced IL-8 production in human colonic epithelial cells. HT29 cells were stimulated with TNF-alpha in the presence or absence of luteolin. IL-8 production was measured by enzyme-linked immunosorbent assay (ELISA) and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis, and the mitogen-activated protein kinases (MAPKs) activation and IkappaB degradation were determined by Western blot analysis. NF-kappaB activation was assessed by the electrophoretic motility shift assay (EMSA). Luteolin suppressed TNF-alpha-induced IL-8 production in dose-dependent manner. In addition, luteolin inhibited TNF-alpha-induced phosphorylation of p38 MAPK and extracellular-regulated kinases (ERK), IkappaB degradation, and NF-kappaB activation. These results suggest that luteolin has the inhibitory effects on TNF-alpha-induced IL-8 production in the intestinal epithelial cells through blockade in the phosphorylation of MAPKs, following IkappaB degradation and NF-kappaB activation. | lld:pubmed |
| pubmed-article:15589482 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15589482 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15589482 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15589482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15589482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15589482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15589482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15589482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15589482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15589482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15589482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15589482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15589482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15589482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15589482 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15589482 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15589482 | pubmed:issn | 1567-5769 | lld:pubmed |
| pubmed-article:15589482 | pubmed:author | pubmed-author:KimDae-KiDK | lld:pubmed |
| pubmed-article:15589482 | pubmed:author | pubmed-author:KimTae-HyunTH | lld:pubmed |
| pubmed-article:15589482 | pubmed:author | pubmed-author:ChoiSuck-Chei... | lld:pubmed |
| pubmed-article:15589482 | pubmed:author | pubmed-author:NahYong-HoYH | lld:pubmed |
| pubmed-article:15589482 | pubmed:author | pubmed-author:LeeYoung-MiYM | lld:pubmed |
| pubmed-article:15589482 | pubmed:author | pubmed-author:YunKi-JungKJ | lld:pubmed |
| pubmed-article:15589482 | pubmed:author | pubmed-author:KimJin-AJA | lld:pubmed |
| pubmed-article:15589482 | pubmed:author | pubmed-author:ParkHye-JungH... | lld:pubmed |
| pubmed-article:15589482 | pubmed:author | pubmed-author:KangOk-HwaOH | lld:pubmed |
| pubmed-article:15589482 | pubmed:author | pubmed-author:ChoiYeon-AYA | lld:pubmed |
| pubmed-article:15589482 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15589482 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:15589482 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15589482 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15589482 | pubmed:pagination | 209-17 | lld:pubmed |
| pubmed-article:15589482 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15589482 | pubmed:meshHeading | pubmed-meshheading:15589482... | lld:pubmed |
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| pubmed-article:15589482 | pubmed:meshHeading | pubmed-meshheading:15589482... | lld:pubmed |
| pubmed-article:15589482 | pubmed:meshHeading | pubmed-meshheading:15589482... | lld:pubmed |
| pubmed-article:15589482 | pubmed:meshHeading | pubmed-meshheading:15589482... | lld:pubmed |
| pubmed-article:15589482 | pubmed:meshHeading | pubmed-meshheading:15589482... | lld:pubmed |
| pubmed-article:15589482 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15589482 | pubmed:articleTitle | Inhibitory effect of luteolin on TNF-alpha-induced IL-8 production in human colon epithelial cells. | lld:pubmed |
| pubmed-article:15589482 | pubmed:affiliation | Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, 570-749, South Korea. | lld:pubmed |
| pubmed-article:15589482 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15589482 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15589482 | lld:pubmed |
