| pubmed-article:15586304 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15586304 | lifeskim:mentions | umls-concept:C1564874 | lld:lifeskim |
| pubmed-article:15586304 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:15586304 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15586304 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:15586304 | lifeskim:mentions | umls-concept:C0085196 | lld:lifeskim |
| pubmed-article:15586304 | lifeskim:mentions | umls-concept:C0282151 | lld:lifeskim |
| pubmed-article:15586304 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:15586304 | lifeskim:mentions | umls-concept:C1335824 | lld:lifeskim |
| pubmed-article:15586304 | lifeskim:mentions | umls-concept:C1705822 | lld:lifeskim |
| pubmed-article:15586304 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15586304 | pubmed:dateCreated | 2005-5-3 | lld:pubmed |
| pubmed-article:15586304 | pubmed:abstractText | Direct intracerebral administration of sonic hedgehog (SHH) reduces 6-OHDA and MPTP toxicity to nigral dopaminergic cells in rats and primates. To determine whether transfection of the DNA sequence for SHH using viral vectors also protects against 6-OHDA toxicity, a type 2 adeno- associated virus (AAV) incorporating 600 base pairs of N-terminal SHH DNA was generated to induce SHH expression in rat striatum.AAV-SHH was injected into the striatum, 3 weeks prior to the initiation of an unilateral partial 6-OHDA nigro-striatal lesion. Animals receiving 4x10(7) viral particles of AAV-SHH showed a reduction in (+)-amphetamine induced ipsilateral turning over 4 weeks, when compared to animals receiving vehicle or a LacZ encoding vector. Following vehicle or AAV-LacZ administration, 6-OHDA caused a marked loss of striatal dopamine content and nigral tyrosine hydroxylase (TH) immunopositive cells. Following treatment with 4x10(7) viral particles of AAV-SHH the loss of striatal dopamine content was reduced and there was marked preservation of nigral dopaminergic cells. However, administration of 4x10(8) particles of AAV-SHH did not cause a significant change in (+)-amphetamine-induced rotation, striatal dopamine levels or the number of nigral TH immunoreactive cells following 6-OHDA lesioning compared to vehicle or AAV-LacZ treated animals. The results show that SHH delivered via a viral vector can protect dopaminergic neurons against 6-OHDA toxicity and suggest that this could be developed into a novel treatment for PD. However, the effects maybe dose limited due to uncoupling of hedgehog receptor signalling at higher levels of SHH expression. | lld:pubmed |
| pubmed-article:15586304 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15586304 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15586304 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15586304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15586304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15586304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15586304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15586304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15586304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15586304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15586304 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15586304 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15586304 | pubmed:issn | 0300-9564 | lld:pubmed |
| pubmed-article:15586304 | pubmed:author | pubmed-author:JennerPP | lld:pubmed |
| pubmed-article:15586304 | pubmed:author | pubmed-author:HuangCC | lld:pubmed |
| pubmed-article:15586304 | pubmed:author | pubmed-author:GaldesAA | lld:pubmed |
| pubmed-article:15586304 | pubmed:author | pubmed-author:DassBB | lld:pubmed |
| pubmed-article:15586304 | pubmed:author | pubmed-author:BarsoumJJ | lld:pubmed |
| pubmed-article:15586304 | pubmed:author | pubmed-author:EngberT MTM | lld:pubmed |
| pubmed-article:15586304 | pubmed:author | pubmed-author:IravaniM MMM | lld:pubmed |
| pubmed-article:15586304 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15586304 | pubmed:volume | 112 | lld:pubmed |
| pubmed-article:15586304 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15586304 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15586304 | pubmed:pagination | 763-78 | lld:pubmed |
| pubmed-article:15586304 | pubmed:dateRevised | 2009-11-3 | lld:pubmed |
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| pubmed-article:15586304 | pubmed:meshHeading | pubmed-meshheading:15586304... | lld:pubmed |
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| pubmed-article:15586304 | pubmed:meshHeading | pubmed-meshheading:15586304... | lld:pubmed |
| pubmed-article:15586304 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15586304 | pubmed:articleTitle | Sonic hedgehog delivered by an adeno-associated virus protects dopaminergic neurones against 6-OHDA toxicity in the rat. | lld:pubmed |
| pubmed-article:15586304 | pubmed:affiliation | Neurodegenerative Diseases Research Centre, GKT School of Biomedical Sciences, King's College, London, United Kingdom. | lld:pubmed |
| pubmed-article:15586304 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15586304 | lld:pubmed |
