| pubmed-article:15585661 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15585661 | lifeskim:mentions | umls-concept:C0013846 | lld:lifeskim |
| pubmed-article:15585661 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:15585661 | lifeskim:mentions | umls-concept:C0025270 | lld:lifeskim |
| pubmed-article:15585661 | lifeskim:mentions | umls-concept:C1547239 | lld:lifeskim |
| pubmed-article:15585661 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:15585661 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:15585661 | pubmed:dateCreated | 2004-12-8 | lld:pubmed |
| pubmed-article:15585661 | pubmed:abstractText | 2-methyl-1,4-naphthoquinone (menadione, MQ) was linked to synthetic oligonucleotides and exposed to near-UV light to generate base radical cations in DNA. This model system of electron transfer induced alkali-labile breaks at GG doublets, similar to anthraquinone and metallointercalators systems. In sharp contrast to other systems, the photolysis of MQ-DNA duplexes gave interstrand cross-links and alkali-labile breaks at bases on the complementary strand opposite the MQ moiety. For sequences with an internal MQ, the formation of cross-links with A and C opposite the MQ moiety was 2- to 3-fold greater than that with G and T. The yield of cross-links was more than 10-fold greater than that of breaks opposite MQ, which in turn was more than 2-fold greater than breaks at GG doublets. The yield of damage at GG doublets greatly increased for a sequence with a terminal MQ. The distribution of base damage was measured by enzymatic digestion and HPLC analysis (dAdo > dThd > dGuo > dCyd). The formation of novel products in MQ-DNA duplexes was attributed to the ability of excited MQ to generate the radical cations of all four DNA bases; thus, this photochemical reaction provides an ideal model system to study the effects of ionizing radiation and one-electron oxidants. | lld:pubmed |
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| pubmed-article:15585661 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15585661 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15585661 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15585661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15585661 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15585661 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:15585661 | pubmed:author | pubmed-author:BergeronFranç... | lld:pubmed |
| pubmed-article:15585661 | pubmed:author | pubmed-author:WagnerJ... | lld:pubmed |
| pubmed-article:15585661 | pubmed:author | pubmed-author:HuntingDarel... | lld:pubmed |
| pubmed-article:15585661 | pubmed:author | pubmed-author:HoudeDanielD | lld:pubmed |
| pubmed-article:15585661 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15585661 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:15585661 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15585661 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15585661 | pubmed:pagination | 6154-263 | lld:pubmed |
| pubmed-article:15585661 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15585661 | pubmed:meshHeading | pubmed-meshheading:15585661... | lld:pubmed |
| pubmed-article:15585661 | pubmed:meshHeading | pubmed-meshheading:15585661... | lld:pubmed |
| pubmed-article:15585661 | pubmed:meshHeading | pubmed-meshheading:15585661... | lld:pubmed |
| pubmed-article:15585661 | pubmed:meshHeading | pubmed-meshheading:15585661... | lld:pubmed |
| pubmed-article:15585661 | pubmed:meshHeading | pubmed-meshheading:15585661... | lld:pubmed |
| pubmed-article:15585661 | pubmed:meshHeading | pubmed-meshheading:15585661... | lld:pubmed |
| pubmed-article:15585661 | pubmed:meshHeading | pubmed-meshheading:15585661... | lld:pubmed |
| pubmed-article:15585661 | pubmed:meshHeading | pubmed-meshheading:15585661... | lld:pubmed |
| pubmed-article:15585661 | pubmed:meshHeading | pubmed-meshheading:15585661... | lld:pubmed |
| pubmed-article:15585661 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15585661 | pubmed:articleTitle | Electron transfer in DNA duplexes containing 2-methyl-1,4-naphthoquinone. | lld:pubmed |
| pubmed-article:15585661 | pubmed:affiliation | Group in the Radiation Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4. | lld:pubmed |
| pubmed-article:15585661 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15585661 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
