| pubmed-article:1556007 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1556007 | lifeskim:mentions | umls-concept:C0003308 | lld:lifeskim |
| pubmed-article:1556007 | lifeskim:mentions | umls-concept:C1524059 | lld:lifeskim |
| pubmed-article:1556007 | lifeskim:mentions | umls-concept:C0010762 | lld:lifeskim |
| pubmed-article:1556007 | lifeskim:mentions | umls-concept:C0023025 | lld:lifeskim |
| pubmed-article:1556007 | lifeskim:mentions | umls-concept:C0534137 | lld:lifeskim |
| pubmed-article:1556007 | lifeskim:mentions | umls-concept:C1417050 | lld:lifeskim |
| pubmed-article:1556007 | lifeskim:mentions | umls-concept:C0205549 | lld:lifeskim |
| pubmed-article:1556007 | lifeskim:mentions | umls-concept:C0205296 | lld:lifeskim |
| pubmed-article:1556007 | lifeskim:mentions | umls-concept:C0302945 | lld:lifeskim |
| pubmed-article:1556007 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1556007 | pubmed:dateCreated | 1992-5-5 | lld:pubmed |
| pubmed-article:1556007 | pubmed:abstractText | From a Penicillium sp. we identified a new series of antifungals having a tetrahydropyran skeleton with an alkenyl side chain. We elucidated the mode of action of Ro 09-1470, the most active compound of the series. Treatment of Candida albicans with the compound caused an accumulation of C-14 methyl intermediates of ergosterol at concentrations of which no significant interference with the biosyntheses of other macromolecules and respiration was observed. P450 lanosterol C-14 demethylase (P450(14DM)) activity was inhibited and furthermore, the binding of Ro 09-1470 to the heme of the enzyme was demonstrated by a difference spectrum. We conclude that Ro 09-1470 is the first natural antifungal that inhibits the P450(14DM) of fungi. | lld:pubmed |
| pubmed-article:1556007 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1556007 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1556007 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1556007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1556007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1556007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1556007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1556007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1556007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1556007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1556007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1556007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1556007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1556007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1556007 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1556007 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1556007 | pubmed:issn | 0021-8820 | lld:pubmed |
| pubmed-article:1556007 | pubmed:author | pubmed-author:ShimadaHH | lld:pubmed |
| pubmed-article:1556007 | pubmed:author | pubmed-author:AokiYY | lld:pubmed |
| pubmed-article:1556007 | pubmed:author | pubmed-author:ArisawaMM | lld:pubmed |
| pubmed-article:1556007 | pubmed:author | pubmed-author:SekineYY | lld:pubmed |
| pubmed-article:1556007 | pubmed:author | pubmed-author:NakayamaNN | lld:pubmed |
| pubmed-article:1556007 | pubmed:author | pubmed-author:YamazakiTT | lld:pubmed |
| pubmed-article:1556007 | pubmed:author | pubmed-author:KondohMM | lld:pubmed |
| pubmed-article:1556007 | pubmed:author | pubmed-author:SudohYY | lld:pubmed |
| pubmed-article:1556007 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1556007 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:1556007 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1556007 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1556007 | pubmed:pagination | 160-70 | lld:pubmed |
| pubmed-article:1556007 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:1556007 | pubmed:meshHeading | pubmed-meshheading:1556007-... | lld:pubmed |
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| pubmed-article:1556007 | pubmed:meshHeading | pubmed-meshheading:1556007-... | lld:pubmed |
| pubmed-article:1556007 | pubmed:meshHeading | pubmed-meshheading:1556007-... | lld:pubmed |
| pubmed-article:1556007 | pubmed:meshHeading | pubmed-meshheading:1556007-... | lld:pubmed |
| pubmed-article:1556007 | pubmed:meshHeading | pubmed-meshheading:1556007-... | lld:pubmed |
| pubmed-article:1556007 | pubmed:meshHeading | pubmed-meshheading:1556007-... | lld:pubmed |
| pubmed-article:1556007 | pubmed:meshHeading | pubmed-meshheading:1556007-... | lld:pubmed |
| pubmed-article:1556007 | pubmed:meshHeading | pubmed-meshheading:1556007-... | lld:pubmed |
| pubmed-article:1556007 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1556007 | pubmed:articleTitle | A new series of natural antifungals that inhibit P450 lanosterol C-14 demethylase. II. Mode of action. | lld:pubmed |
| pubmed-article:1556007 | pubmed:affiliation | Nippon Roche Research Center, Kamakura, Japan. | lld:pubmed |
| pubmed-article:1556007 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1556007 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1556007 | lld:pubmed |
