| pubmed-article:15558022 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15558022 | lifeskim:mentions | umls-concept:C0079281 | lld:lifeskim |
| pubmed-article:15558022 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:15558022 | lifeskim:mentions | umls-concept:C0007102 | lld:lifeskim |
| pubmed-article:15558022 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:15558022 | lifeskim:mentions | umls-concept:C0018284 | lld:lifeskim |
| pubmed-article:15558022 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:15558022 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15558022 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15558022 | pubmed:dateCreated | 2005-1-20 | lld:pubmed |
| pubmed-article:15558022 | pubmed:abstractText | Endothelin-1 (EDN1) is a growth factor that is frequently produced by cancer cells and plays a critical role in tumorigenesis. However, the molecular mechanism controlling the expression of EDN1 in cancers is unknown. Constitutive activation of beta-catenin pathway is responsible for the initiation of the vast majority of colon cancers. Here we show that the EDN1 gene is directly regulated by beta-catenin in colon cancer cells. A specific DNA element within the EDN1 promoter is required for activation, and is associated with beta-catenin's cognate DNA binding partner, TCF4, in vivo. Inhibition of beta-catenin signaling results in lowered expression of EDN1, while enhancement of beta-catenin signaling leads to further activation of the gene. Significantly elevated EDN1 expression occurs in 80% of primary human colon cancers, consistent with it being a direct target of beta-catenin. Furthermore, EDN1 is able to rescue colon cancer cells from growth arrest and apoptosis resulting from inhibition of beta-catenin signaling, implicating a key role of EDN1 in promoting the oncogenic function of beta-catenin. These results indicate EDN1 overexpression as a major cause in colon cancers and reveal further details of the genetic programs responsible for tumorigenesis of colon cancers. | lld:pubmed |
| pubmed-article:15558022 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15558022 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15558022 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15558022 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15558022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15558022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15558022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15558022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15558022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15558022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15558022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15558022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15558022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15558022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15558022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15558022 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15558022 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15558022 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:15558022 | pubmed:author | pubmed-author:RenBingB | lld:pubmed |
| pubmed-article:15558022 | pubmed:author | pubmed-author:XiongHuiH | lld:pubmed |
| pubmed-article:15558022 | pubmed:author | pubmed-author:KimTae HoonTH | lld:pubmed |
| pubmed-article:15558022 | pubmed:author | pubmed-author:ZhangZhuohuaZ | lld:pubmed |
| pubmed-article:15558022 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15558022 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:15558022 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:15558022 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15558022 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15558022 | pubmed:pagination | 597-604 | lld:pubmed |
| pubmed-article:15558022 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15558022 | pubmed:meshHeading | pubmed-meshheading:15558022... | lld:pubmed |
| pubmed-article:15558022 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15558022 | pubmed:articleTitle | beta-Catenin activates the growth factor endothelin-1 in colon cancer cells. | lld:pubmed |
| pubmed-article:15558022 | pubmed:affiliation | Laboratory of Gene Regulation, Ludwig Institute for Cancer Research, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA. | lld:pubmed |
| pubmed-article:15558022 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15558022 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15558022 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:15558022 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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