| pubmed-article:15550464 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15550464 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15550464 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:15550464 | lifeskim:mentions | umls-concept:C0410256 | lld:lifeskim |
| pubmed-article:15550464 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:15550464 | lifeskim:mentions | umls-concept:C2699488 | lld:lifeskim |
| pubmed-article:15550464 | lifeskim:mentions | umls-concept:C1140999 | lld:lifeskim |
| pubmed-article:15550464 | pubmed:issue | Pt 3 | lld:pubmed |
| pubmed-article:15550464 | pubmed:dateCreated | 2005-1-27 | lld:pubmed |
| pubmed-article:15550464 | pubmed:abstractText | We tested the hypotheses that: (1) neutrophil accumulation after contraction-induced muscle injury is dependent on the beta(2) integrin CD18, (2) neutrophils contribute to muscle injury and oxidative damage after contraction-induced muscle injury, and (3) neutrophils aid the resolution of contraction-induced muscle injury. These hypotheses were tested by exposing extensor digitorum longus (EDL) muscles of mice deficient in CD18 (CD18(-/-); Itgb2(tm1Bay)) and of wild type mice (C57BL/6) to in situ lengthening contractions and by quantifying markers of muscle inflammation, injury, oxidative damage and regeneration/repair. Neutrophil concentrations were significantly elevated in wild type mice at 6 h and 3 days post-lengthening contractions; however, neutrophils remained at control levels at these time points in CD18-/- mice. These data indicate that CD18 is required for neutrophil accumulation after contraction-induced muscle injury. Histological and functional (isometric force deficit) signs of muscle injury and total carbonyl content, a marker of oxidative damage, were significantly higher in wild type relative to CD18-/- mice 3 days after lengthening contractions. These data show that neutrophils exacerbate contraction-induced muscle injury. After statistically controlling for differences in the force deficit at 3 days, wild type mice also demonstrated a higher force deficit at 7 days, a lower percentage of myofibres expressing embryonic myosin heavy chain at 3 and 7 days, and a smaller cross sectional area of central nucleated myofibres at 14 days relative to CD18-/- mice. These observations suggest that neutrophils impair the restoration of muscle structure and function after injury. In conclusion, neutrophil accumulation after contraction-induced muscle injury is dependent on CD18. Furthermore, neutrophils appear to contribute to muscle injury and impair some of the events associated with the resolution of contraction-induced muscle injury. | lld:pubmed |
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| pubmed-article:15550464 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15550464 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15550464 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15550464 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15550464 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15550464 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:15550464 | pubmed:author | pubmed-author:PizzaFrancis... | lld:pubmed |
| pubmed-article:15550464 | pubmed:author | pubmed-author:KohTimothy... | lld:pubmed |
| pubmed-article:15550464 | pubmed:author | pubmed-author:PetersonJenni... | lld:pubmed |
| pubmed-article:15550464 | pubmed:author | pubmed-author:BaasJoel HJH | lld:pubmed |
| pubmed-article:15550464 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15550464 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15550464 | pubmed:volume | 562 | lld:pubmed |
| pubmed-article:15550464 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15550464 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15550464 | pubmed:pagination | 899-913 | lld:pubmed |
| pubmed-article:15550464 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:15550464 | pubmed:meshHeading | pubmed-meshheading:15550464... | lld:pubmed |
| pubmed-article:15550464 | pubmed:year | 2005 | lld:pubmed |
