Linked Life Data

15530971

Source:http://linkedlifedata.com/resource/pubmed/id/15530971

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pubmed-article:15530971pubmed:abstractTextVibrio vulnificus is an opportunistic human pathogen causing septicemia, and the infection is characterized by formation of the edematous skin lesions on limbs. This pathogenic species secretes a thermolysin-like metalloprotease as a virulence determinant. The metalloprotease was confirmed to activate human factor XII-plasma kallikrein-kinin cascade that results in liberation of bradykinin, a chemical mediator enhancing the vascular permeability, from high-molecular weight kininogen. Namely, the metalloprotease showed to generate active fragments by cleavage of Arg-Ile, Arg-Val or Gly-Leu peptide bond in human zymogens (plasma prekallikrein and factor XII). In spite of induction of the sufficient vascular permeability-enhancing and edema-forming reaction in the guinea pig model, a serine protease from V. parahaemolyticus, a human pathogen causing primarily watery diarrhea, showed far less ability to activate and to cleave the human zymogens. These results in part may explain why only V. vulnificus often causes serious edematous skin damages in humans.lld:pubmed
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pubmed-article:15530971pubmed:authorpubmed-author:YamadaHidenor...lld:pubmed
pubmed-article:15530971pubmed:authorpubmed-author:MiyoshiShin-i...lld:pubmed
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pubmed-article:15530971pubmed:pagination887-93lld:pubmed
pubmed-article:15530971pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15530971pubmed:articleTitleGeneration of active fragments from human zymogens in the bradykinin-generating cascade by extracellular proteases from Vibrio vulnificus and V. parahaemolyticus.lld:pubmed
pubmed-article:15530971pubmed:affiliationFaculty of Pharmaceutical Sciences, Okayama University, Tsushima-Naka, Okayama 700-8530, Japan. miyoshi@pharm.okayama-u.ac.jplld:pubmed
pubmed-article:15530971pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15530971pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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