| pubmed-article:15520822 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15520822 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:15520822 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:15520822 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15520822 | lifeskim:mentions | umls-concept:C0031268 | lld:lifeskim |
| pubmed-article:15520822 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:15520822 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:15520822 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:15520822 | lifeskim:mentions | umls-concept:C0032743 | lld:lifeskim |
| pubmed-article:15520822 | lifeskim:mentions | umls-concept:C0021044 | lld:lifeskim |
| pubmed-article:15520822 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:15520822 | lifeskim:mentions | umls-concept:C2350660 | lld:lifeskim |
| pubmed-article:15520822 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15520822 | pubmed:dateCreated | 2004-11-24 | lld:pubmed |
| pubmed-article:15520822 | pubmed:abstractText | This study aimed to evaluate tumour hypoxia by comparing [(18)F]Fluoromisonidazole uptake measured using positron emission tomography ([(18)F]FMISO-PET) with immunohistochemical (IHC) staining techniques. Syngeneic rhabdomyosarcoma (R1) tumour pieces were transplanted subcutaneously in the flanks of WAG/Rij rats. Tumours were analysed at volumes between 0.9 and 7.3 cm(3). Hypoxic volumes were defined using a 3D region of interest on 2 h postinjection [(18)F]FMISO-PET images, applying different thresholds (1.2-3.0). Monoclonal antibodies to pimonidazole (PIMO) and carbonic anhydrase IX (CA IX), exogenous and endogenous markers of hypoxia, respectively, were used for IHC staining. Marker-positive fractions were microscopically measured for each tumour, and hypoxic volumes were calculated. A heterogeneous distribution of hypoxia was observed both with histology and [(18)F]FMISO autoradiography. A statistically significant correlation (P<0.05) was obtained between the hypoxic volumes defined with [(18)F]FMISO-PET and the volumes derived from the PIMO-stained tumour sections (r=0.9066; P=0.0001), regardless of the selected threshold between 1.4 and 2.2. A similar observation was made with the CA IX staining (r=0.8636; P=0.0006). The relationship found between [(18)F]FMISO-PET and PIMO- and additionally CA IX-derived hypoxic volumes in rat rhabdomyosarcomas indicates the value of the noninvasive imaging method to measure hypoxia in whole tumours. | lld:pubmed |
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| pubmed-article:15520822 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15520822 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15520822 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15520822 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15520822 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:15520822 | pubmed:author | pubmed-author:DupontPP | lld:pubmed |
| pubmed-article:15520822 | pubmed:author | pubmed-author:DuboisLL | lld:pubmed |
| pubmed-article:15520822 | pubmed:author | pubmed-author:MortelmansLL | lld:pubmed |
| pubmed-article:15520822 | pubmed:author | pubmed-author:BormansGG | lld:pubmed |
| pubmed-article:15520822 | pubmed:author | pubmed-author:LanduytWW | lld:pubmed |
| pubmed-article:15520822 | pubmed:author | pubmed-author:VerbekenEE | lld:pubmed |
| pubmed-article:15520822 | pubmed:author | pubmed-author:FlamenPP | lld:pubmed |
| pubmed-article:15520822 | pubmed:author | pubmed-author:HaustermansKK | lld:pubmed |
| pubmed-article:15520822 | pubmed:author | pubmed-author:VermaelenPP | lld:pubmed |
| pubmed-article:15520822 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15520822 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:15520822 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:15520822 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15520822 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15520822 | pubmed:pagination | 1947-54 | lld:pubmed |
| pubmed-article:15520822 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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