| pubmed-article:15519528 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15519528 | lifeskim:mentions | umls-concept:C0042149 | lld:lifeskim |
| pubmed-article:15519528 | lifeskim:mentions | umls-concept:C0206701 | lld:lifeskim |
| pubmed-article:15519528 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:15519528 | lifeskim:mentions | umls-concept:C0012929 | lld:lifeskim |
| pubmed-article:15519528 | lifeskim:mentions | umls-concept:C0332183 | lld:lifeskim |
| pubmed-article:15519528 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:15519528 | pubmed:dateCreated | 2004-11-2 | lld:pubmed |
| pubmed-article:15519528 | pubmed:abstractText | The mitochondria plays a role in apoptosis. Its genome is also more susceptible to mutations because of high levels of reactive oxygen species and limited repair mechanisms. The D-loop of mitochondrial DNA (mtDNA) contains essential transcription and replication elements, and mutations in this region might alter the rate of DNA replication. We examined genetic alterations in the D-loop region of mtDNA in uterine serous carcinoma (USC) samples and their paired normal adjacent endometrium. DNA was extracted after laser-capture microdissection of paraffin-embedded tissues from eight patients with USC. The entire D-loop genome was amplified using nine pairs of overlapping primers. Denatured polymerase chain reaction (PCR) products were subjected to single-strand conformation polymorphism (SSCP) analysis. Somatic mtDNA alterations were detected in five tumours (63%). Our study indicates that mtDNA D-loop sequence alterations occur at a high frequency in USC suggesting that mtDNA mutations may play a role in the development of USC. | lld:pubmed |
| pubmed-article:15519528 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15519528 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15519528 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15519528 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15519528 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15519528 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15519528 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15519528 | pubmed:issn | 0959-8049 | lld:pubmed |
| pubmed-article:15519528 | pubmed:author | pubmed-author:OdunsiKunleK | lld:pubmed |
| pubmed-article:15519528 | pubmed:author | pubmed-author:SchwartzPeter... | lld:pubmed |
| pubmed-article:15519528 | pubmed:author | pubmed-author:LeleShashikan... | lld:pubmed |
| pubmed-article:15519528 | pubmed:author | pubmed-author:ZhengKarlK | lld:pubmed |
| pubmed-article:15519528 | pubmed:author | pubmed-author:PejovicTanjaT | lld:pubmed |
| pubmed-article:15519528 | pubmed:author | pubmed-author:DillonDeborah... | lld:pubmed |
| pubmed-article:15519528 | pubmed:author | pubmed-author:CostaJoseJ | lld:pubmed |
| pubmed-article:15519528 | pubmed:author | pubmed-author:IntenganMaril... | lld:pubmed |
| pubmed-article:15519528 | pubmed:author | pubmed-author:MarchettiDavi... | lld:pubmed |
| pubmed-article:15519528 | pubmed:author | pubmed-author:LadnerDaniela... | lld:pubmed |
| pubmed-article:15519528 | pubmed:author | pubmed-author:FairchildTrac... | lld:pubmed |
| pubmed-article:15519528 | pubmed:author | pubmed-author:EasleySamanth... | lld:pubmed |
| pubmed-article:15519528 | pubmed:author | pubmed-author:DillonDionneD | lld:pubmed |
| pubmed-article:15519528 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15519528 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:15519528 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15519528 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15519528 | pubmed:pagination | 2519-24 | lld:pubmed |
| pubmed-article:15519528 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15519528 | pubmed:meshHeading | pubmed-meshheading:15519528... | lld:pubmed |
| pubmed-article:15519528 | pubmed:meshHeading | pubmed-meshheading:15519528... | lld:pubmed |
| pubmed-article:15519528 | pubmed:meshHeading | pubmed-meshheading:15519528... | lld:pubmed |
| pubmed-article:15519528 | pubmed:meshHeading | pubmed-meshheading:15519528... | lld:pubmed |
| pubmed-article:15519528 | pubmed:meshHeading | pubmed-meshheading:15519528... | lld:pubmed |
| pubmed-article:15519528 | pubmed:meshHeading | pubmed-meshheading:15519528... | lld:pubmed |
| pubmed-article:15519528 | pubmed:meshHeading | pubmed-meshheading:15519528... | lld:pubmed |
| pubmed-article:15519528 | pubmed:meshHeading | pubmed-meshheading:15519528... | lld:pubmed |
| pubmed-article:15519528 | pubmed:meshHeading | pubmed-meshheading:15519528... | lld:pubmed |
| pubmed-article:15519528 | pubmed:meshHeading | pubmed-meshheading:15519528... | lld:pubmed |
| pubmed-article:15519528 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15519528 | pubmed:articleTitle | Somatic D-loop mitochondrial DNA mutations are frequent in uterine serous carcinoma. | lld:pubmed |
| pubmed-article:15519528 | pubmed:affiliation | Division of Gynecologic Oncology, Yale University School of Medicine, New Haven, CT, USA. | lld:pubmed |
| pubmed-article:15519528 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15519528 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15519528 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15519528 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15519528 | lld:pubmed |
