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pubmed-article:15510162pubmed:abstractTextGermline mutations in the BRCA1, BRCA2 and Fanconi anaemia genes confer cancer susceptibility, and the proteins encoded by these genes have distinct functions in related DNA-repair processes. Emerging evidence indicates that these processes are disrupted by numerous mechanisms in sporadic cancers. Collectively, there are properties that define 'BRCAness' - that is, traits that some sporadic cancers share with those occurring in either BRCA1- or BRCA2-mutation carriers. These common properties might have important implications for the clinical management of these cancers.lld:pubmed
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pubmed-article:15510162pubmed:articleTitleHallmarks of 'BRCAness' in sporadic cancers.lld:pubmed
pubmed-article:15510162pubmed:affiliationThe Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.lld:pubmed
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