| pubmed-article:15500628 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15500628 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15500628 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:15500628 | lifeskim:mentions | umls-concept:C0006033 | lld:lifeskim |
| pubmed-article:15500628 | lifeskim:mentions | umls-concept:C0036087 | lld:lifeskim |
| pubmed-article:15500628 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15500628 | lifeskim:mentions | umls-concept:C0040203 | lld:lifeskim |
| pubmed-article:15500628 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:15500628 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:15500628 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15500628 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:15500628 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:15500628 | lifeskim:mentions | umls-concept:C0282509 | lld:lifeskim |
| pubmed-article:15500628 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15500628 | pubmed:dateCreated | 2004-10-25 | lld:pubmed |
| pubmed-article:15500628 | pubmed:abstractText | We recently described the inhibition of host B lymphocytes by Ixodes ricinus tick saliva. In this study, we characterized the factor responsible for this activity and examined the modulation of lipopolysaccharide (LPS)- and Borrelia burgdorferi outer surface protein (Osp)-induced proliferation of naive murine B lymphocytes by an enriched fraction of this factor. The B-lymphocyte inhibitory activity was destroyed by trypsin treatment, indicating that a proteinaceous factor was responsible for this activity. The removal of glutathione-S-transferase (GST) from tick salivary glands extracts (SGE) showed that this B-cell inhibitory protein (BIP) was not a GST. Gel filtration liquid chromatography indicated that BIP has a native molecular weight of approximately 18,000. An enrichment protocol, using a combination of anion-exchange and reverse-phase liquid chromatography, was established. BIP-enriched fractions did not suppress T-cell proliferation. Delayed addition of BIP-enriched fractions, up to 7 hr after LPS addition, inhibited the proliferation of isolated B cells. BIP-enriched fractions dramatically inhibited both OspA- and OspC-induced proliferation of isolated B cells. These results strongly suggest that BIP may facilitate B. burgdorferi transmission by preventing B-cell activation, and also highlights the potential of BIP as a therapeutic agent in B-cell maladies. | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15500628 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15500628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15500628 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15500628 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15500628 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:15500628 | pubmed:author | pubmed-author:LiversidgeJan... | lld:pubmed |
| pubmed-article:15500628 | pubmed:author | pubmed-author:HannierSigrid... | lld:pubmed |
| pubmed-article:15500628 | pubmed:author | pubmed-author:BowmanAlan... | lld:pubmed |
| pubmed-article:15500628 | pubmed:author | pubmed-author:SternbergJere... | lld:pubmed |
| pubmed-article:15500628 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15500628 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:15500628 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15500628 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15500628 | pubmed:pagination | 401-8 | lld:pubmed |
| pubmed-article:15500628 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:meshHeading | pubmed-meshheading:15500628... | lld:pubmed |
| pubmed-article:15500628 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15500628 | pubmed:articleTitle | Characterization of the B-cell inhibitory protein factor in Ixodes ricinus tick saliva: a potential role in enhanced Borrelia burgdoferi transmission. | lld:pubmed |
| pubmed-article:15500628 | pubmed:affiliation | School of Biological Science, Zoology, University of Aberdeen, UK. | lld:pubmed |
| pubmed-article:15500628 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15500628 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15500628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15500628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15500628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15500628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15500628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15500628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15500628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15500628 | lld:pubmed |
