| pubmed-article:15488234 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15488234 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:15488234 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15488234 | pubmed:dateCreated | 2004-10-18 | lld:pubmed |
| pubmed-article:15488234 | pubmed:abstractText | We have developed an agar-embedding method for brain-slicing that minimizes the geometrical distortions which arise from handling and slicing the fixed postmortem brain. To facilitate postmortem brain-magnetic resonance imaging (MRI) co-registration, each hemisphere is processed separately. We embed the fixed brain hemisphere with reference markers in agar. The block containing the brain and markers is sliced at a fixed interval using a rotary slicer. Each slice is photographed with a high-resolution digital camera. The digital images are realigned as a 3-dimensional volume via a control point-based registration method for multi-slice registration. The realigned multiple slices of the reconstructed postmortem hemisphere are then co-registered to corresponding slices of an in vivo reference MRI-volume. We illustrate these postmortem MRI-brain co-registration methods to correlate in vivo T2-weighted MRI hyperintensities in gray and white matter with underlying pathology. For design-based stereology, the volume of interest (VOI) is defined using reproducible anatomical boundaries. This method is suitable for stereologic measures of structures ranging from defined nuclei to whole brain. | lld:pubmed |
| pubmed-article:15488234 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15488234 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15488234 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15488234 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15488234 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15488234 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15488234 | pubmed:issn | 0165-0270 | lld:pubmed |
| pubmed-article:15488234 | pubmed:author | pubmed-author:SinghMM | lld:pubmed |
| pubmed-article:15488234 | pubmed:author | pubmed-author:ChuiH CHC | lld:pubmed |
| pubmed-article:15488234 | pubmed:author | pubmed-author:ZarowCC | lld:pubmed |
| pubmed-article:15488234 | pubmed:author | pubmed-author:NESW RWR | lld:pubmed |
| pubmed-article:15488234 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15488234 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:15488234 | pubmed:volume | 139 | lld:pubmed |
| pubmed-article:15488234 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15488234 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15488234 | pubmed:pagination | 209-15 | lld:pubmed |
| pubmed-article:15488234 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15488234 | pubmed:meshHeading | pubmed-meshheading:15488234... | lld:pubmed |
| pubmed-article:15488234 | pubmed:meshHeading | pubmed-meshheading:15488234... | lld:pubmed |
| pubmed-article:15488234 | pubmed:meshHeading | pubmed-meshheading:15488234... | lld:pubmed |
| pubmed-article:15488234 | pubmed:meshHeading | pubmed-meshheading:15488234... | lld:pubmed |
| pubmed-article:15488234 | pubmed:meshHeading | pubmed-meshheading:15488234... | lld:pubmed |
| pubmed-article:15488234 | pubmed:meshHeading | pubmed-meshheading:15488234... | lld:pubmed |
| pubmed-article:15488234 | pubmed:meshHeading | pubmed-meshheading:15488234... | lld:pubmed |
| pubmed-article:15488234 | pubmed:meshHeading | pubmed-meshheading:15488234... | lld:pubmed |
| pubmed-article:15488234 | pubmed:meshHeading | pubmed-meshheading:15488234... | lld:pubmed |
| pubmed-article:15488234 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15488234 | pubmed:articleTitle | A standardized method for brain-cutting suitable for both stereology and MRI-brain co-registration. | lld:pubmed |
| pubmed-article:15488234 | pubmed:affiliation | Department of Neurology, Rancho Los Amigos National Rehabilitation Center, University of Southern California, Downey, CA 90242, USA. zarow@usc.edu | lld:pubmed |
| pubmed-article:15488234 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15488234 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15488234 | lld:pubmed |
