| pubmed-article:15474458 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15474458 | lifeskim:mentions | umls-concept:C0243052 | lld:lifeskim |
| pubmed-article:15474458 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:15474458 | lifeskim:mentions | umls-concept:C1367307 | lld:lifeskim |
| pubmed-article:15474458 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15474458 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15474458 | pubmed:dateCreated | 2004-10-11 | lld:pubmed |
| pubmed-article:15474458 | pubmed:abstractText | Hepatitis C virus (HCV) infection is a leading cause a of chronic liver disease worldwide. The main therapeutic regimen is the combination of interferon alpha (IFN) and the nucleoside analog, Ribavirin. IFN initiates an intracellular antiviral state by the JAK-STAT signaling pathway, including a presumed role for STAT1 and STAT2. We have previously shown that the STAT3 activation occurs during IFN treatment of human hepatoma cells, suggesting that the STAT3-mediated pathway is relevant to IFN-induced antiviral activity. In this study, we investigate the role of activated STAT3 in the induction of anti-HCV activity in human hepatoma cells. We demonstrate that the STAT3 activation is involved in efficient IFN-induced anti-HCV activity. Using an inducible, cytokine-independent, STAT3 activation system, in which the entire coding region of STAT3 is fused with the ligand-binding domain of the estrogen receptor, we demonstrate that: activated STAT3 is tightly regulated in a stably transfected cell line by an estrogen analog, 4-HT; activated STAT3 initiates efficient anti-HCV activity in a HCV subgenomic replicon cell line; and activation of STAT3 is associated with the induction of a potential antiviral gene, 1-8U. In addition, we show that the cytokine IL-6, a potent STAT3 activator, inhibits HCV subgenomic RNA replication through STAT3 activation and ERK pathway. These results strongly suggest that STAT3 activation is capable of initiating intracellular antiviral pathways. | lld:pubmed |
| pubmed-article:15474458 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15474458 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15474458 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15474458 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15474458 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15474458 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15474458 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:15474458 | pubmed:author | pubmed-author:LiuChenC | lld:pubmed |
| pubmed-article:15474458 | pubmed:author | pubmed-author:TeradaNaohiro... | lld:pubmed |
| pubmed-article:15474458 | pubmed:author | pubmed-author:ZhuHaizhenH | lld:pubmed |
| pubmed-article:15474458 | pubmed:author | pubmed-author:ShangXianzhan... | lld:pubmed |
| pubmed-article:15474458 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15474458 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:15474458 | pubmed:volume | 324 | lld:pubmed |
| pubmed-article:15474458 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15474458 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15474458 | pubmed:pagination | 518-28 | lld:pubmed |
| pubmed-article:15474458 | pubmed:dateRevised | 2008-9-10 | lld:pubmed |
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| pubmed-article:15474458 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15474458 | pubmed:articleTitle | STAT3 induces anti-hepatitis C viral activity in liver cells. | lld:pubmed |
| pubmed-article:15474458 | pubmed:affiliation | Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA. | lld:pubmed |
| pubmed-article:15474458 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15474458 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15474458 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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