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pubmed-article:15473910pubmed:abstractTextThe management of unresectable or metastatic gastrointestinal stromal tumors (GISTs) has previously been difficult as they are resistant to conventional chemotherapy and radiation. The development of imatinib mesylate has made a major impact on the management of advanced GISTs. It is apparent that there are sanctuary sites such as the central nervous system where imatinib does not achieve adequate concentrations. We describe the case of a man with metastatic GIST who experienced multiple cerebral relapses of disease while systemic disease progression appeared to be controlled by imatinib.lld:pubmed
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pubmed-article:15473910pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:15473910pubmed:articleTitleCerebral relapse of metastatic gastrointestinal stromal tumor during treatment with imatinib mesylate: case report.lld:pubmed
pubmed-article:15473910pubmed:affiliationMedical Oncology Unit, Canberra Hospital, :Yamba Drive, Garran, ACT, Australia. brett_hughes@health.qld.gov.au.lld:pubmed
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