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pubmed-article:15472360pubmed:abstractTextA new approach, short-oligonucleotide-ligation assay on DNA chip (SOLAC), is developed to detect mutations in rifampin-resistant Mycobacterium tuberculosis. The method needs only four common probes to detect 15 mutational variants of the rpoB gene within 12 h. Fifty-five rifampin-resistant M. tuberculosis isolates were analyzed, resulting in 87.3% accuracy and 83.6% concordance relative to DNA sequencing.lld:pubmed
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pubmed-article:15472360pubmed:articleTitleMultiplex detection of mutations in clinical isolates of rifampin-resistant Mycobacterium tuberculosis by short oligonucleotide ligation assay on DNA chips.lld:pubmed
pubmed-article:15472360pubmed:affiliationWuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.lld:pubmed
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