| pubmed-article:15459124 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15459124 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15459124 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:15459124 | lifeskim:mentions | umls-concept:C0020275 | lld:lifeskim |
| pubmed-article:15459124 | lifeskim:mentions | umls-concept:C0043119 | lld:lifeskim |
| pubmed-article:15459124 | lifeskim:mentions | umls-concept:C0237477 | lld:lifeskim |
| pubmed-article:15459124 | lifeskim:mentions | umls-concept:C0870509 | lld:lifeskim |
| pubmed-article:15459124 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:15459124 | pubmed:dateCreated | 2004-12-3 | lld:pubmed |
| pubmed-article:15459124 | pubmed:abstractText | Werner syndrome (WS) is a rare disease caused by the lack of a functional nuclear WS protein (WRN). WS is characterized by the early onset of premature aging signs and a high incidence of sarcomas. WS diploid fibroblasts have a short life span and extensive genomic instability. Mammalian cells are continuously exposed to reactive oxygen species (ROS), which represent human mutagens and are thought to be a major contributor to the aging process. Hydrogen peroxide (H2O2) is a common ROS intermediate generated by various forms of oxidative stress. In response to H2O2-induced DNA damage, normal human diploid fibroblasts follow a pathway leading to irreversible proliferation arrest and premature senescence. Here we show that in contrast to normal human fibroblasts, WS diploid fibroblasts continue proliferating after extensive H2O2-induced DNA damage and accumulate oxidative DNA lesions. A direct role of WRN in this abnormal cellular response to H2O2 is demonstrated by interfering with WRN expression in normal human fibroblasts. We propose a role for WRN in the detection and/or processing of oxidative DNA lesions and in cellular responses to H2O2 as they relate to some of the phenotypical aspects of WS cells. | lld:pubmed |
| pubmed-article:15459124 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15459124 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15459124 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15459124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15459124 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15459124 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15459124 | pubmed:issn | 1530-6860 | lld:pubmed |
| pubmed-article:15459124 | pubmed:author | pubmed-author:MayAlfredA | lld:pubmed |
| pubmed-article:15459124 | pubmed:author | pubmed-author:BohrVilhelm... | lld:pubmed |
| pubmed-article:15459124 | pubmed:author | pubmed-author:GrandoriCarla... | lld:pubmed |
| pubmed-article:15459124 | pubmed:author | pubmed-author:Von... | lld:pubmed |
| pubmed-article:15459124 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15459124 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:15459124 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15459124 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15459124 | pubmed:pagination | 1970-2 | lld:pubmed |
| pubmed-article:15459124 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15459124 | pubmed:meshHeading | pubmed-meshheading:15459124... | lld:pubmed |
| pubmed-article:15459124 | pubmed:meshHeading | pubmed-meshheading:15459124... | lld:pubmed |
| pubmed-article:15459124 | pubmed:meshHeading | pubmed-meshheading:15459124... | lld:pubmed |
| pubmed-article:15459124 | pubmed:meshHeading | pubmed-meshheading:15459124... | lld:pubmed |
| pubmed-article:15459124 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15459124 | pubmed:articleTitle | Werner syndrome cells escape hydrogen peroxide-induced cell proliferation arrest. | lld:pubmed |
| pubmed-article:15459124 | pubmed:affiliation | Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA. | lld:pubmed |
| pubmed-article:15459124 | pubmed:publicationType | Journal Article | lld:pubmed |
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