| pubmed-article:15383681 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15383681 | lifeskim:mentions | umls-concept:C0035553 | lld:lifeskim |
| pubmed-article:15383681 | lifeskim:mentions | umls-concept:C0079925 | lld:lifeskim |
| pubmed-article:15383681 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:15383681 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:15383681 | pubmed:dateCreated | 2004-9-22 | lld:pubmed |
| pubmed-article:15383681 | pubmed:abstractText | Evidence is presented that morpholino, 2'-O-methyl, phosphorothioate, and RNA antisense oligonucleotides can direct site-specific -1 translational frameshifting when annealed to mRNA downstream from sequences where the P- and A-site tRNAs are both capable of repairing with -1 frame codons. The efficiency of ribosomes shifting into the new frame can be as high as 40%, determined by the sequence of the frameshift site, as well as the location, sequence composition, and modification of the antisense oligonucleotide. These results demonstrate that a perfect duplex formed by complementary oligonucleotides is sufficient to induce high level -1 frameshifting. The implications for the mechanism of action of natural programmed translational frameshift stimulators are discussed. | lld:pubmed |
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| pubmed-article:15383681 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15383681 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15383681 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15383681 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15383681 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15383681 | pubmed:issn | 1355-8382 | lld:pubmed |
| pubmed-article:15383681 | pubmed:author | pubmed-author:GestelandRaym... | lld:pubmed |
| pubmed-article:15383681 | pubmed:author | pubmed-author:AtkinsJohn... | lld:pubmed |
| pubmed-article:15383681 | pubmed:author | pubmed-author:HowardMichael... | lld:pubmed |
| pubmed-article:15383681 | pubmed:copyrightInfo | Copyright 2004 RNA Society | lld:pubmed |
| pubmed-article:15383681 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15383681 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:15383681 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15383681 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15383681 | pubmed:pagination | 1653-61 | lld:pubmed |
| pubmed-article:15383681 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15383681 | pubmed:meshHeading | pubmed-meshheading:15383681... | lld:pubmed |
| pubmed-article:15383681 | pubmed:meshHeading | pubmed-meshheading:15383681... | lld:pubmed |
| pubmed-article:15383681 | pubmed:meshHeading | pubmed-meshheading:15383681... | lld:pubmed |
| pubmed-article:15383681 | pubmed:meshHeading | pubmed-meshheading:15383681... | lld:pubmed |
| pubmed-article:15383681 | pubmed:meshHeading | pubmed-meshheading:15383681... | lld:pubmed |
| pubmed-article:15383681 | pubmed:meshHeading | pubmed-meshheading:15383681... | lld:pubmed |
| pubmed-article:15383681 | pubmed:meshHeading | pubmed-meshheading:15383681... | lld:pubmed |
| pubmed-article:15383681 | pubmed:meshHeading | pubmed-meshheading:15383681... | lld:pubmed |
| pubmed-article:15383681 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15383681 | pubmed:articleTitle | Efficient stimulation of site-specific ribosome frameshifting by antisense oligonucleotides. | lld:pubmed |
| pubmed-article:15383681 | pubmed:affiliation | Department of Human Genetics, University of Utah, 15 N. 2030 E., Rm. 7410, Salt Lake City, UT 84112-5330, USA. mhoward@genetics.utah.edu | lld:pubmed |
| pubmed-article:15383681 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15383681 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15383681 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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