| pubmed-article:15375583 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15375583 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:15375583 | lifeskim:mentions | umls-concept:C0254610 | lld:lifeskim |
| pubmed-article:15375583 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:15375583 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:15375583 | lifeskim:mentions | umls-concept:C0338106 | lld:lifeskim |
| pubmed-article:15375583 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15375583 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:15375583 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
| pubmed-article:15375583 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:15375583 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:15375583 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:15375583 | lifeskim:mentions | umls-concept:C0872192 | lld:lifeskim |
| pubmed-article:15375583 | lifeskim:mentions | umls-concept:C0683201 | lld:lifeskim |
| pubmed-article:15375583 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:15375583 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15375583 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15375583 | pubmed:dateCreated | 2004-9-17 | lld:pubmed |
| pubmed-article:15375583 | pubmed:abstractText | Although interleukin (IL)-15 augments innate and acquired immunities, IL-15 expression is controlled at the levels of transcription, translation and intracellular trafficking. We constructed plasmid vectors encoding the murine mature-IL-15 cDNA linked to an Igkappa leader sequence and full-length murine IL-15 cDNA to evaluate the efficacy of the mature-IL-15 vector. Weakly immunogenic colon 26 cells were transfected with the above-mentioned vectors or with empty vector (mock). Transfectants with mature-IL-15 produced significantly higher levels of IL-15 than did transfectants with full-length IL-15. When injected into syngeneic BALB/c mice, transfectants secreting high levels of IL-15 were rejected completely. Depletion of natural killer cells or CD4+ T cells did not affect the growth of transfectants. In contrast, transfectants treated with anti-CD8 antibody re-grew 1 month later after implantation. These findings indicate that CD8+ T cells are required for complete rejection of the tumor. Gene therapy with transfectants expressing mature-IL-15 containing the Igkappa leader sequence may be useful as a tumor vaccine. | lld:pubmed |
| pubmed-article:15375583 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15375583 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15375583 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15375583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15375583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15375583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15375583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15375583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15375583 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15375583 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15375583 | pubmed:issn | 1107-3756 | lld:pubmed |
| pubmed-article:15375583 | pubmed:author | pubmed-author:IizukaNorioN | lld:pubmed |
| pubmed-article:15375583 | pubmed:author | pubmed-author:HazamaShoichi... | lld:pubmed |
| pubmed-article:15375583 | pubmed:author | pubmed-author:YoshinoShigef... | lld:pubmed |
| pubmed-article:15375583 | pubmed:author | pubmed-author:OkaMasaakiM | lld:pubmed |
| pubmed-article:15375583 | pubmed:author | pubmed-author:YoshimuraKiyo... | lld:pubmed |
| pubmed-article:15375583 | pubmed:author | pubmed-author:ArakiAtsuhiro... | lld:pubmed |
| pubmed-article:15375583 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15375583 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:15375583 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15375583 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15375583 | pubmed:pagination | 571-6 | lld:pubmed |
| pubmed-article:15375583 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15375583 | pubmed:meshHeading | pubmed-meshheading:15375583... | lld:pubmed |
| pubmed-article:15375583 | pubmed:meshHeading | pubmed-meshheading:15375583... | lld:pubmed |
| pubmed-article:15375583 | pubmed:meshHeading | pubmed-meshheading:15375583... | lld:pubmed |
| pubmed-article:15375583 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15375583 | pubmed:articleTitle | Tumor secreting high levels of IL-15 induces specific immunity to low immunogenic colon adenocarcinoma via CD8+ T cells. | lld:pubmed |
| pubmed-article:15375583 | pubmed:affiliation | Department of Surgery II, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan. | lld:pubmed |
| pubmed-article:15375583 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15375583 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15375583 | lld:pubmed |
