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pubmed-article:15354638pubmed:abstractTextThis report describes a case of severe coagulopathy and bleeding related to the intraoperative use of topically applied thrombin. Commercial thrombin preparations contaminated with bovine factor V have been shown to stimulate the production of antibodies directed against factor V. These antibodies can cause coagulopathy. Our patient developed antibodies against factor V after intraoperative exposure to topical thrombin. The resulting antibody-mediated depletion of factor V caused a severe and refractory coagulopathy. Vascular surgeons should be aware that the use of topical bovine thrombin can cause severe coagulopathy.lld:pubmed
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pubmed-article:15354638pubmed:articleTitleSevere coagulopathy following intraoperative use of topical thrombin.lld:pubmed
pubmed-article:15354638pubmed:affiliationDivision of Vascular Surgery, University of Utah Health Sciences Center, Salt Lake City, UT 84103, USA. mark.sarfati@hsc.utah.edulld:pubmed
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