| pubmed-article:1534816 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1534816 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1534816 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:1534816 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:1534816 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:1534816 | lifeskim:mentions | umls-concept:C1512966 | lld:lifeskim |
| pubmed-article:1534816 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:1534816 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:1534816 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1534816 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:1534816 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:1534816 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:1534816 | lifeskim:mentions | umls-concept:C1655505 | lld:lifeskim |
| pubmed-article:1534816 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:1534816 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:1534816 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1534816 | pubmed:dateCreated | 1992-7-13 | lld:pubmed |
| pubmed-article:1534816 | pubmed:abstractText | To delineate the scope of the human intraovarian IL-1 system we used a solution hybridization/RNase protection assay to test for expression of the genes encoding IL-1, its type I receptor (IL-1R), and its receptor antagonist (IL-1RA). IL-1 transcripts were not detected in whole ovarian material from days 4 or 12 of an unstimulated menstrual cycle but transcripts (IL-1 beta much greater than IL-11 alpha) were detected in preovulatory follicular aspirates from gonadotropin-stimulated cycles. Concurrently obtained peripheral monocytes did not contain IL-1 beta transcripts but macrophage-depleted follicular aspirates did, thus implicating the granulosa cells as the site of IL-1 expression. IL-1R transcripts were detected in RNA from whole ovaries and follicular aspirates but not in RNA from peripheral monocytes. IL-1RA transcripts were detected in whole ovarian material as well as in macrophage-free follicular aspirates. Cultured human granulosa and theca cells did not contain mRNA for IL-1 beta or IL-1RA but did contain mRNA for IL-1R. Treatment of cell cultures with forskolin (25 microM) induced IL-1 beta transcripts in granulosa but not theca cells. Forskolin also increased the basal levels of IL-1R transcripts in both granulosa and theca cells but did not induce IL-RA transcripts in either cell type. Taken together, these findings reveal the existence of a complete, highly compartmentalized, hormonally dependent intraovarian IL-1 system replete with ligands, receptor, and receptor antagonist. | lld:pubmed |
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| pubmed-article:1534816 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1534816 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1534816 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1534816 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1534816 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1534816 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1534816 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:1534816 | pubmed:author | pubmed-author:KatzEE | lld:pubmed |
| pubmed-article:1534816 | pubmed:author | pubmed-author:HurwitzAA | lld:pubmed |
| pubmed-article:1534816 | pubmed:author | pubmed-author:AdashiE YEY | lld:pubmed |
| pubmed-article:1534816 | pubmed:author | pubmed-author:GarciaJ EJE | lld:pubmed |
| pubmed-article:1534816 | pubmed:author | pubmed-author:HernandezE... | lld:pubmed |
| pubmed-article:1534816 | pubmed:author | pubmed-author:RicciarelliEE | lld:pubmed |
| pubmed-article:1534816 | pubmed:author | pubmed-author:BoteroLL | lld:pubmed |
| pubmed-article:1534816 | pubmed:author | pubmed-author:RohanRR | lld:pubmed |
| pubmed-article:1534816 | pubmed:author | pubmed-author:McAllisterJ... | lld:pubmed |
| pubmed-article:1534816 | pubmed:author | pubmed-author:LoukidesJJ | lld:pubmed |
| pubmed-article:1534816 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1534816 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:1534816 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1534816 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1534816 | pubmed:pagination | 1746-54 | lld:pubmed |
| pubmed-article:1534816 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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