Linked Life Data

15312760

Source:http://linkedlifedata.com/resource/pubmed/id/15312760

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15312760rdf:typepubmed:Citationlld:pubmed
pubmed-article:15312760lifeskim:mentionsumls-concept:C0080125lld:lifeskim
pubmed-article:15312760lifeskim:mentionsumls-concept:C0032433lld:lifeskim
pubmed-article:15312760lifeskim:mentionsumls-concept:C0456389lld:lifeskim
pubmed-article:15312760lifeskim:mentionsumls-concept:C0039679lld:lifeskim
pubmed-article:15312760lifeskim:mentionsumls-concept:C0678553lld:lifeskim
pubmed-article:15312760lifeskim:mentionsumls-concept:C0185026lld:lifeskim
pubmed-article:15312760pubmed:issue1lld:pubmed
pubmed-article:15312760pubmed:dateCreated2004-8-17lld:pubmed
pubmed-article:15312760pubmed:abstractTextPolyamines are abundant metabolites that directly influence gene expression. Although the role of polyamines in DNA condensation is well known, their role in RNA folding is less understood. Non-denaturing gel electrophoresis was used to monitor the equilibrium folding transitions of the Tetrahymena ribozyme in the presence of polyamines. All of the polyamines tested induce near-native structures that readily convert to the native conformation in Mg(2+). The stability of the folded structure increases with the charge of the polyamine and decreases with the size of the polyamine. When the counterion excluded volume becomes large, the transition to the native state does not go to completion even under favorable folding conditions. Brownian dynamics simulations of a model polyelectrolyte suggest that the kinetics of counterion-mediated collapse and the dimensions of the collapsed RNA chains depend on the structure of the counterion. The results are consistent with delocalized condensation of polyamines around the RNA. However, the effective charge of the counterions is lowered by their excluded volume. The stability of the folded RNA is enhanced when the spacing between amino groups matches the distance between adjacent phosphate groups. These results show how changes in intracellular polyamine concentrations could alter RNA folding pathways.lld:pubmed
pubmed-article:15312760pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15312760pubmed:languageenglld:pubmed
pubmed-article:15312760pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15312760pubmed:citationSubsetIMlld:pubmed
pubmed-article:15312760pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15312760pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15312760pubmed:statusMEDLINElld:pubmed
pubmed-article:15312760pubmed:monthJullld:pubmed
pubmed-article:15312760pubmed:issn0022-2836lld:pubmed
pubmed-article:15312760pubmed:authorpubmed-author:ThirumalaiDDlld:pubmed
pubmed-article:15312760pubmed:authorpubmed-author:WoodsonSarah...lld:pubmed
pubmed-article:15312760pubmed:authorpubmed-author:LeeNam-KyungN...lld:pubmed
pubmed-article:15312760pubmed:authorpubmed-author:KoculiEdaElld:pubmed
pubmed-article:15312760pubmed:issnTypePrintlld:pubmed
pubmed-article:15312760pubmed:day30lld:pubmed
pubmed-article:15312760pubmed:volume341lld:pubmed
pubmed-article:15312760pubmed:ownerNLMlld:pubmed
pubmed-article:15312760pubmed:authorsCompleteYlld:pubmed
pubmed-article:15312760pubmed:pagination27-36lld:pubmed
pubmed-article:15312760pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:15312760pubmed:meshHeadingpubmed-meshheading:15312760...lld:pubmed
pubmed-article:15312760pubmed:meshHeadingpubmed-meshheading:15312760...lld:pubmed
pubmed-article:15312760pubmed:meshHeadingpubmed-meshheading:15312760...lld:pubmed
pubmed-article:15312760pubmed:meshHeadingpubmed-meshheading:15312760...lld:pubmed
pubmed-article:15312760pubmed:meshHeadingpubmed-meshheading:15312760...lld:pubmed
pubmed-article:15312760pubmed:meshHeadingpubmed-meshheading:15312760...lld:pubmed
pubmed-article:15312760pubmed:meshHeadingpubmed-meshheading:15312760...lld:pubmed
pubmed-article:15312760pubmed:year2004lld:pubmed
pubmed-article:15312760pubmed:articleTitleFolding of the Tetrahymena ribozyme by polyamines: importance of counterion valence and size.lld:pubmed
pubmed-article:15312760pubmed:affiliationT. C. Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.lld:pubmed
pubmed-article:15312760pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15312760pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:15312760pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15312760lld:pubmed