| pubmed-article:15305572 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15305572 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:15305572 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:15305572 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15305572 | lifeskim:mentions | umls-concept:C1519090 | lld:lifeskim |
| pubmed-article:15305572 | lifeskim:mentions | umls-concept:C1979804 | lld:lifeskim |
| pubmed-article:15305572 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:15305572 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:15305572 | pubmed:dateCreated | 2004-8-12 | lld:pubmed |
| pubmed-article:15305572 | pubmed:abstractText | This paper describes the effects of beta-adrenergic and peptidergic inputs on serotonin (5-HT) synthesis, outflow and metabolism into melatonin in cultured dissociated rat pinealocytes. The spontaneous outflow of 5-HT from pinealocytes was high as demonstrated by the elevated levels of extracellular 5-HT accumulated in the medium (about 5 ng/h/70,000 pineal cells). The beta-adrenergic agonist isoproterenol (ISO) used at concentrations up to 10(-6) M induced a moderate (+20-40%) increase in intra- and extracellular 5-HT levels together with a large release of melatonin. At a higher ISO stimulation (10(-5) M), the intra- and extracellular levels of 5-HT were significantly (-25-30%) reduced whereas melatonin secretion was dramatically increased. This is interpreted as a large 5-HT mobilization for melatonin synthesis and release, consequently reducing both the intracellular pool and outflow of 5-HT. The peptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) up to 10(-7) M induced always a moderate (+20-30%) increase in intra- and extracellular levels of 5-HT. However, the use of nM concentrations of VIP or PACAP together with 10(-6) M ISO induced a decrease in 5-HT outflow (-25-30%) and a dramatic increase in melatonin secretion as did 10(-5) M ISO alone. Neuropeptide Y (NPY) is another pineal peptide which induced a stimulation of 5-HT outflow (+30-40%) although its effect on melatonin release was marginal. The above results are discussed in term of the multineuronal regulation of the synthetic and secretory activities of the rat pineal gland. | lld:pubmed |
| pubmed-article:15305572 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15305572 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15305572 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15305572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15305572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15305572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15305572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15305572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15305572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15305572 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15305572 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15305572 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15305572 | pubmed:issn | 0953-8194 | lld:pubmed |
| pubmed-article:15305572 | pubmed:author | pubmed-author:PevetPP | lld:pubmed |
| pubmed-article:15305572 | pubmed:author | pubmed-author:SimonneauxVV | lld:pubmed |
| pubmed-article:15305572 | pubmed:author | pubmed-author:MiguetJ GJG | lld:pubmed |
| pubmed-article:15305572 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15305572 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:15305572 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15305572 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15305572 | pubmed:pagination | 537-43 | lld:pubmed |
| pubmed-article:15305572 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:15305572 | pubmed:meshHeading | pubmed-meshheading:15305572... | lld:pubmed |
| pubmed-article:15305572 | pubmed:meshHeading | pubmed-meshheading:15305572... | lld:pubmed |
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| pubmed-article:15305572 | pubmed:meshHeading | pubmed-meshheading:15305572... | lld:pubmed |
| pubmed-article:15305572 | pubmed:meshHeading | pubmed-meshheading:15305572... | lld:pubmed |
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| pubmed-article:15305572 | pubmed:meshHeading | pubmed-meshheading:15305572... | lld:pubmed |
| pubmed-article:15305572 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:15305572 | pubmed:articleTitle | Peptidergic modulation of serotonin release from cultured rat pinealocytes. | lld:pubmed |
| pubmed-article:15305572 | pubmed:affiliation | Neurobiologie des Fonctions Rythmiques et Saisonnières, URA-CNRS 1332, Université Louis Pasteur, 12 rue de l'Université, 67000 Strasbourg, France. | lld:pubmed |
| pubmed-article:15305572 | pubmed:publicationType | Journal Article | lld:pubmed |
