| pubmed-article:15300228 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15300228 | lifeskim:mentions | umls-concept:C0472699 | lld:lifeskim |
| pubmed-article:15300228 | lifeskim:mentions | umls-concept:C2350466 | lld:lifeskim |
| pubmed-article:15300228 | lifeskim:mentions | umls-concept:C2004454 | lld:lifeskim |
| pubmed-article:15300228 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:15300228 | pubmed:dateCreated | 2004-9-16 | lld:pubmed |
| pubmed-article:15300228 | pubmed:abstractText | Human Valpha24+ natural killer T (NKT) cells have an invariant T-cell receptor-alpha chain and are activated in a CD1d-restricted manner. Valpha24+ NKT cells are thought to regulate immune responses and to play important roles in the induction of allograft tolerance. In this report, we analyzed the recovery of Valpha24+ NKT cells after hematopoietic stem cell transplantation and its correlation with graft-versus-host disease (GVHD). Patients who received a dose-reduced conditioning regimen, antithymocyte globulin- or CAMPATH-1H-containing conditioning regimen were excluded. NKT cells were reconstituted within 1 month after transplantation in peripheral blood stem cell transplantation recipients, while their numbers remained low for more than 1 year in bone marrow transplantation (BMT) recipients. The number of Valpha24+ NKT cells in BMT recipients with acute GVHD was lower than that in patients without acute GVHD, and both the CD4+ and CD4- Valpha24+ NKT subsets were significantly reduced. With regard to chronic GVHD, BMT recipients with extensive GVHD had significantly fewer Valpha24+ NKT cells than other patients. Furthermore, the number of CD4+ Valpha24+ NKT cells was also significantly reduced in patients with chronic extensive GVHD. Our results raise the possibility that the number of Valpha24+ NKT cells could be related to the development of GVHD. | lld:pubmed |
| pubmed-article:15300228 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15300228 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15300228 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15300228 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15300228 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15300228 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15300228 | pubmed:issn | 0268-3369 | lld:pubmed |
| pubmed-article:15300228 | pubmed:author | pubmed-author:OgawaSS | lld:pubmed |
| pubmed-article:15300228 | pubmed:author | pubmed-author:TanakaYY | lld:pubmed |
| pubmed-article:15300228 | pubmed:author | pubmed-author:TakahashiTT | lld:pubmed |
| pubmed-article:15300228 | pubmed:author | pubmed-author:HiraiHH | lld:pubmed |
| pubmed-article:15300228 | pubmed:author | pubmed-author:ChibaSS | lld:pubmed |
| pubmed-article:15300228 | pubmed:author | pubmed-author:MiuraOO | lld:pubmed |
| pubmed-article:15300228 | pubmed:author | pubmed-author:SakamakiHH | lld:pubmed |
| pubmed-article:15300228 | pubmed:author | pubmed-author:KandaYY | lld:pubmed |
| pubmed-article:15300228 | pubmed:author | pubmed-author:HaraguchiKK | lld:pubmed |
| pubmed-article:15300228 | pubmed:author | pubmed-author:HirumaKK | lld:pubmed |
| pubmed-article:15300228 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15300228 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:15300228 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15300228 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15300228 | pubmed:pagination | 595-602 | lld:pubmed |
| pubmed-article:15300228 | pubmed:meshHeading | pubmed-meshheading:15300228... | lld:pubmed |
| pubmed-article:15300228 | pubmed:meshHeading | pubmed-meshheading:15300228... | lld:pubmed |
| pubmed-article:15300228 | pubmed:meshHeading | pubmed-meshheading:15300228... | lld:pubmed |
| pubmed-article:15300228 | pubmed:meshHeading | pubmed-meshheading:15300228... | lld:pubmed |
| pubmed-article:15300228 | pubmed:meshHeading | pubmed-meshheading:15300228... | lld:pubmed |
| pubmed-article:15300228 | pubmed:meshHeading | pubmed-meshheading:15300228... | lld:pubmed |
| pubmed-article:15300228 | pubmed:meshHeading | pubmed-meshheading:15300228... | lld:pubmed |
| pubmed-article:15300228 | pubmed:meshHeading | pubmed-meshheading:15300228... | lld:pubmed |
| pubmed-article:15300228 | pubmed:meshHeading | pubmed-meshheading:15300228... | lld:pubmed |
| pubmed-article:15300228 | pubmed:meshHeading | pubmed-meshheading:15300228... | lld:pubmed |
| pubmed-article:15300228 | pubmed:meshHeading | pubmed-meshheading:15300228... | lld:pubmed |
| pubmed-article:15300228 | pubmed:meshHeading | pubmed-meshheading:15300228... | lld:pubmed |
| pubmed-article:15300228 | pubmed:meshHeading | pubmed-meshheading:15300228... | lld:pubmed |
| pubmed-article:15300228 | pubmed:meshHeading | pubmed-meshheading:15300228... | lld:pubmed |
| pubmed-article:15300228 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15300228 | pubmed:articleTitle | Recovery of Valpha24+ NKT cells after hematopoietic stem cell transplantation. | lld:pubmed |
| pubmed-article:15300228 | pubmed:affiliation | Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan. kyoh-tky@umin.ac.jp | lld:pubmed |
| pubmed-article:15300228 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15300228 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15300228 | lld:pubmed |
