| pubmed-article:15299974 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15299974 | lifeskim:mentions | umls-concept:C0026200 | lld:lifeskim |
| pubmed-article:15299974 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:15299974 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:15299974 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:15299974 | pubmed:issue | Pt 1 | lld:pubmed |
| pubmed-article:15299974 | pubmed:dateCreated | 2004-8-9 | lld:pubmed |
| pubmed-article:15299974 | pubmed:abstractText | The three-dimensional crystal structure of the single-stranded DNA-containing ('full') parvovirus, minute virus of mice (MVM), has been determined to 3.5 A resolution. Both full and empty particles of MVM were crystallized in the monoclinic space group C2 with cell dimensions of a = 448.7, b = 416.7, c = 305.3 A and beta = 95.8 degrees. Diffraction data were collected at the Cornell High Energy Synchrotron Source using an oscillation camera. The crystals have a pseudo higher R32 space group in which the particles are situated at two special positions with 32 point symmetry, separated by (1/2)c in the hexagonal setting. The self-rotation function showed that the particles are rotated with respect to each other by 60 degrees around the pseudo threefold axis. Subsequently, a more detailed analysis of the structure amplitudes demonstrated that the correct space-group symmetry is C2 as given above. Only one of the three twofold axes perpendicular to the threefold axis in the pseudo R32 space group is a 'true' crystallographic twofold axis; the other two are only 'local' non-crystallographic symmetry axes. The known canine parvovirus (CPV) structure was used as a phasing model to initiate real-space electron-density averaging phase improvement. The electron density was easily interpretable and clearly showed the amino-acid differences between MVM and CPV, although the final overall correlation coefficient was only 0.63. The structure of MVM has a large amount of icosahedrally ordered DNA, amounting to 22% of the viral genome, which is significantly more than that found in CPV. | lld:pubmed |
| pubmed-article:15299974 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15299974 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15299974 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:15299974 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15299974 | pubmed:issn | 0907-4449 | lld:pubmed |
| pubmed-article:15299974 | pubmed:author | pubmed-author:RossmannM GMG | lld:pubmed |
| pubmed-article:15299974 | pubmed:author | pubmed-author:TattersallPP | lld:pubmed |
| pubmed-article:15299974 | pubmed:author | pubmed-author:WillisM VMV | lld:pubmed |
| pubmed-article:15299974 | pubmed:author | pubmed-author:BrattonJJ | lld:pubmed |
| pubmed-article:15299974 | pubmed:author | pubmed-author:Agbandje-McKe... | lld:pubmed |
| pubmed-article:15299974 | pubmed:author | pubmed-author:Llamas-SaizA... | lld:pubmed |
| pubmed-article:15299974 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15299974 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15299974 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:15299974 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15299974 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15299974 | pubmed:pagination | 93-102 | lld:pubmed |
| pubmed-article:15299974 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
| pubmed-article:15299974 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:15299974 | pubmed:articleTitle | Structure determination of minute virus of mice. | lld:pubmed |
| pubmed-article:15299974 | pubmed:affiliation | Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-1392, USA. | lld:pubmed |
| pubmed-article:15299974 | pubmed:publicationType | Journal Article | lld:pubmed |
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