| pubmed-article:15294155 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15294155 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:15294155 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:15294155 | lifeskim:mentions | umls-concept:C1522424 | lld:lifeskim |
| pubmed-article:15294155 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:15294155 | lifeskim:mentions | umls-concept:C1326912 | lld:lifeskim |
| pubmed-article:15294155 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:15294155 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:15294155 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:15294155 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15294155 | pubmed:dateCreated | 2004-8-5 | lld:pubmed |
| pubmed-article:15294155 | pubmed:abstractText | A link between inflammation and cancer has long been suspected, but its molecular nature remained ill defined. A key player in inflammation is transcription factor NF-kappaB whose activity is triggered in response to infectious agents and proinflammatory cytokines via the IkappaB kinase (IKK) complex. Using a colitis-associated cancer model, we show that although deletion of IKKbeta in intestinal epithelial cells does not decrease inflammation, it leads to a dramatic decrease in tumor incidence without affecting tumor size. This is linked to increased epithelial apoptosis during tumor promotion. Deleting IKKbeta in myeloid cells, however, results in a significant decrease in tumor size. This deletion diminishes expression of proinflammatory cytokines that may serve as tumor growth factors, without affecting apoptosis. Thus, specific inactivation of the IKK/NF-kappaB pathway in two different cell types can attenuate formation of inflammation-associated tumors. In addition to suppressing apoptosis in advanced tumors, IKKbeta may link inflammation to cancer. | lld:pubmed |
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| pubmed-article:15294155 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15294155 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15294155 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15294155 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15294155 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15294155 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:15294155 | pubmed:author | pubmed-author:KagnoffMartin... | lld:pubmed |
| pubmed-article:15294155 | pubmed:author | pubmed-author:EckmannLarsL | lld:pubmed |
| pubmed-article:15294155 | pubmed:author | pubmed-author:KarinMichaelM | lld:pubmed |
| pubmed-article:15294155 | pubmed:author | pubmed-author:GretenTim FTF | lld:pubmed |
| pubmed-article:15294155 | pubmed:author | pubmed-author:GretenFlorian... | lld:pubmed |
| pubmed-article:15294155 | pubmed:author | pubmed-author:LiZhi-WeiZW | lld:pubmed |
| pubmed-article:15294155 | pubmed:author | pubmed-author:ParkJin MoJM | lld:pubmed |
| pubmed-article:15294155 | pubmed:author | pubmed-author:EganLaurence... | lld:pubmed |
| pubmed-article:15294155 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15294155 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:15294155 | pubmed:volume | 118 | lld:pubmed |
| pubmed-article:15294155 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15294155 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15294155 | pubmed:pagination | 285-96 | lld:pubmed |
| pubmed-article:15294155 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15294155 | pubmed:meshHeading | pubmed-meshheading:15294155... | lld:pubmed |
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| pubmed-article:15294155 | pubmed:meshHeading | pubmed-meshheading:15294155... | lld:pubmed |
| pubmed-article:15294155 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15294155 | pubmed:articleTitle | IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. | lld:pubmed |
| pubmed-article:15294155 | pubmed:affiliation | Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla 92093, USA. | lld:pubmed |
| pubmed-article:15294155 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15294155 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15294155 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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