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pubmed-article:15289793pubmed:abstractTextCyclosporine (INN, ciclosporin) increases the systemic exposure of all statins. Therefore rosuvastatin pharmacokinetic parameters were assessed in an open-label trial involving stable heart transplant recipients (> or =6 months after transplant) on an antirejection regimen including cyclosporine. Rosuvastatin has been shown to be a substrate for the human liver transporter organic anion transporting polypeptide C (OATP-C). Inhibition of this transporter could increase plasma concentrations of rosuvastatin. Therefore the effect of cyclosporine on rosuvastatin uptake by cells expressing OATP-C was also examined.lld:pubmed
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pubmed-article:15289793pubmed:articleTitleRosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine.lld:pubmed
pubmed-article:15289793pubmed:affiliationAstraZeneca, Wilmington, Del, USA. steven.simonson@astrazeneca.comlld:pubmed
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