Linked Life Data

15279788

Source:http://linkedlifedata.com/resource/pubmed/id/15279788

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15279788rdf:typepubmed:Citationlld:pubmed
pubmed-article:15279788lifeskim:mentionsumls-concept:C0031715lld:lifeskim
pubmed-article:15279788lifeskim:mentionsumls-concept:C0178539lld:lifeskim
pubmed-article:15279788lifeskim:mentionsumls-concept:C0012860lld:lifeskim
pubmed-article:15279788lifeskim:mentionsumls-concept:C0165675lld:lifeskim
pubmed-article:15279788lifeskim:mentionsumls-concept:C1704632lld:lifeskim
pubmed-article:15279788lifeskim:mentionsumls-concept:C0871261lld:lifeskim
pubmed-article:15279788lifeskim:mentionsumls-concept:C2911692lld:lifeskim
pubmed-article:15279788lifeskim:mentionsumls-concept:C1706817lld:lifeskim
pubmed-article:15279788pubmed:issue8-9lld:pubmed
pubmed-article:15279788pubmed:dateCreated2004-7-28lld:pubmed
pubmed-article:15279788pubmed:abstractTextDefects in cellular DNA metabolism have a direct role in many human disease processes. Impaired responses to DNA damage and basal DNA repair have been implicated as causal factors in diseases with DNA instability like cancer, Fragile X and Huntington's. Replication protein A (RPA) is essential for multiple processes in DNA metabolism including DNA replication, recombination and DNA repair pathways (including nucleotide excision, base excision and double-strand break repair). RPA is a single-stranded DNA-binding protein composed of subunits of 70-, 32- and 14-kDa. RPA binds ssDNA with high affinity and interacts specifically with multiple proteins. Cellular DNA damage causes the N-terminus of the 32-kDa subunit of human RPA to become hyper-phosphorylated. Current data indicates that hyper-phosphorylation causes a change in RPA conformation that down-regulates activity in DNA replication but does not affect DNA repair processes. This suggests that the role of RPA phosphorylation in the cellular response to DNA damage is to help regulate DNA metabolism and promote DNA repair.lld:pubmed
pubmed-article:15279788pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15279788pubmed:languageenglld:pubmed
pubmed-article:15279788pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15279788pubmed:citationSubsetIMlld:pubmed
pubmed-article:15279788pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15279788pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15279788pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15279788pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15279788pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15279788pubmed:statusMEDLINElld:pubmed
pubmed-article:15279788pubmed:issn1568-7864lld:pubmed
pubmed-article:15279788pubmed:authorpubmed-author:WoldMarc SMSlld:pubmed
pubmed-article:15279788pubmed:authorpubmed-author:BinzSara KSKlld:pubmed
pubmed-article:15279788pubmed:authorpubmed-author:SheehanAnne...lld:pubmed
pubmed-article:15279788pubmed:issnTypePrintlld:pubmed
pubmed-article:15279788pubmed:volume3lld:pubmed
pubmed-article:15279788pubmed:ownerNLMlld:pubmed
pubmed-article:15279788pubmed:authorsCompleteYlld:pubmed
pubmed-article:15279788pubmed:pagination1015-24lld:pubmed
pubmed-article:15279788pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:15279788pubmed:meshHeadingpubmed-meshheading:15279788...lld:pubmed
pubmed-article:15279788pubmed:meshHeadingpubmed-meshheading:15279788...lld:pubmed
pubmed-article:15279788pubmed:meshHeadingpubmed-meshheading:15279788...lld:pubmed
pubmed-article:15279788pubmed:meshHeadingpubmed-meshheading:15279788...lld:pubmed
pubmed-article:15279788pubmed:meshHeadingpubmed-meshheading:15279788...lld:pubmed
pubmed-article:15279788pubmed:meshHeadingpubmed-meshheading:15279788...lld:pubmed
pubmed-article:15279788pubmed:meshHeadingpubmed-meshheading:15279788...lld:pubmed
pubmed-article:15279788pubmed:meshHeadingpubmed-meshheading:15279788...lld:pubmed
pubmed-article:15279788pubmed:meshHeadingpubmed-meshheading:15279788...lld:pubmed
pubmed-article:15279788pubmed:meshHeadingpubmed-meshheading:15279788...lld:pubmed
pubmed-article:15279788pubmed:meshHeadingpubmed-meshheading:15279788...lld:pubmed
pubmed-article:15279788pubmed:meshHeadingpubmed-meshheading:15279788...lld:pubmed
pubmed-article:15279788pubmed:meshHeadingpubmed-meshheading:15279788...lld:pubmed
pubmed-article:15279788pubmed:articleTitleReplication protein A phosphorylation and the cellular response to DNA damage.lld:pubmed
pubmed-article:15279788pubmed:affiliationDepartment of Biochemistry, University of Iowa Carver College of Medicine, 3107 MERF, Iowa City, IA 52242, USA.lld:pubmed
pubmed-article:15279788pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15279788pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:15279788pubmed:publicationTypeReviewlld:pubmed
pubmed-article:15279788pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:6117entrezgene:pubmedpubmed-article:15279788lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15279788lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15279788lld:pubmed
More...