| pubmed-article:15275969 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15275969 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15275969 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:15275969 | lifeskim:mentions | umls-concept:C0022567 | lld:lifeskim |
| pubmed-article:15275969 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:15275969 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15275969 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:15275969 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:15275969 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15275969 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15275969 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15275969 | pubmed:dateCreated | 2004-7-27 | lld:pubmed |
| pubmed-article:15275969 | pubmed:abstractText | PD-1 and its ligands, B7-H1/PD-L1 and B7-DC/PD-L2, have been identified recently as CD28-B7 family molecules that are implicated in immune regulation. Lichen planus (LP) is a T cell-mediated chronic inflammatory mucocutaneous disease. We investigated the expression and function of PD-1 and its two ligands in LP. Immunohistochemical examination revealed the abundant expression of PD-1 and B7-H1 in infiltrating T cells and macrophages, and lower-level expression of B7-DC on macrophages in the subepithelium. Interestingly, substantial expression of B7-H1 on keratinocytes (KCs) was found close to the numerous T cell infiltrates in the subepithelium. Unstimulated cultured KCs expressed both B7-H1 and B7-DC, and their expression was upregulated by proinflammatory cytokines, particularly IFN-gamma. The T-cell proliferative responses and IFN-gamma production that were induced by IFN-gamma-treated KCs were augmented preferentially by anti-B7-H1 mAb, but not by anti-B7-DC mAb. These results indicate the regulatory role of B7-H1 on KCs in the interactions with T cells. Our results suggest that the induction of B7-H1 on KCs may play an important role in tolerance induction in the inflamed oral mucosa and skin. | lld:pubmed |
| pubmed-article:15275969 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15275969 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15275969 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15275969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15275969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15275969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15275969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15275969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15275969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15275969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15275969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15275969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15275969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15275969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15275969 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15275969 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15275969 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15275969 | pubmed:issn | 0165-2478 | lld:pubmed |
| pubmed-article:15275969 | pubmed:author | pubmed-author:TakahashiYuzo... | lld:pubmed |
| pubmed-article:15275969 | pubmed:author | pubmed-author:MachidaUtakoU | lld:pubmed |
| pubmed-article:15275969 | pubmed:author | pubmed-author:YokozekiHiroo... | lld:pubmed |
| pubmed-article:15275969 | pubmed:author | pubmed-author:AzumaMiyukiM | lld:pubmed |
| pubmed-article:15275969 | pubmed:author | pubmed-author:OmuraKenK | lld:pubmed |
| pubmed-article:15275969 | pubmed:author | pubmed-author:IwaiHideyukiH | lld:pubmed |
| pubmed-article:15275969 | pubmed:author | pubmed-author:OtsukiNorikoN | lld:pubmed |
| pubmed-article:15275969 | pubmed:author | pubmed-author:TsushimaFumih... | lld:pubmed |
| pubmed-article:15275969 | pubmed:author | pubmed-author:Youngnak-Pibo... | lld:pubmed |
| pubmed-article:15275969 | pubmed:author | pubmed-author:IgarashiHanna... | lld:pubmed |
| pubmed-article:15275969 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15275969 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15275969 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:15275969 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15275969 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15275969 | pubmed:pagination | 215-22 | lld:pubmed |
| pubmed-article:15275969 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:15275969 | pubmed:meshHeading | pubmed-meshheading:15275969... | lld:pubmed |
| pubmed-article:15275969 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15275969 | pubmed:articleTitle | The expression of B7-H1 on keratinocytes in chronic inflammatory mucocutaneous disease and its regulatory role. | lld:pubmed |
| pubmed-article:15275969 | pubmed:affiliation | Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan. | lld:pubmed |
| pubmed-article:15275969 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15275969 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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