| pubmed-article:15265502 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15265502 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:15265502 | lifeskim:mentions | umls-concept:C1373041 | lld:lifeskim |
| pubmed-article:15265502 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:15265502 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:15265502 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:15265502 | pubmed:dateCreated | 2004-7-21 | lld:pubmed |
| pubmed-article:15265502 | pubmed:abstractText | The opioid receptor binding affinities of N-methyl- and N-phenethyl-5-phenylmorphans with a meta-hydroxy substituent [3-(2-methyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (1a), and 3-(2-phenethyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (1b)] were compared with the affinities of four new ligands bearing an ortho- or para-hydroxyl substituent (2-(2-methyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (2a) and 2-(2-phenethyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (2b), 4-(2-methyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (3a), and 4-(2-phenethyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (3b)) that were synthesized from 2-bromoanisole or the known 2-methyl-5-phenyl-2-azabicyclo[3.3.1]nonane (13), respectively. The data indicated that either the electronic state of the phenolic ring is critical for the ligand's interaction with an opioid receptor, or that there must be a specific distance and angle for a hydrogen bond between the phenolic moiety and an amino acid in the binding domain that cannot be altered. | lld:pubmed |
| pubmed-article:15265502 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15265502 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15265502 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15265502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15265502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15265502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15265502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15265502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15265502 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15265502 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15265502 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:15265502 | pubmed:author | pubmed-author:JacobsonArthu... | lld:pubmed |
| pubmed-article:15265502 | pubmed:author | pubmed-author:RiceKenner... | lld:pubmed |
| pubmed-article:15265502 | pubmed:author | pubmed-author:DerschChristi... | lld:pubmed |
| pubmed-article:15265502 | pubmed:author | pubmed-author:RothmanRichar... | lld:pubmed |
| pubmed-article:15265502 | pubmed:author | pubmed-author:KimIn JongIJ | lld:pubmed |
| pubmed-article:15265502 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15265502 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15265502 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:15265502 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15265502 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15265502 | pubmed:pagination | 4543-50 | lld:pubmed |
| pubmed-article:15265502 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15265502 | pubmed:meshHeading | pubmed-meshheading:15265502... | lld:pubmed |
| pubmed-article:15265502 | pubmed:meshHeading | pubmed-meshheading:15265502... | lld:pubmed |
| pubmed-article:15265502 | pubmed:meshHeading | pubmed-meshheading:15265502... | lld:pubmed |
| pubmed-article:15265502 | pubmed:meshHeading | pubmed-meshheading:15265502... | lld:pubmed |
| pubmed-article:15265502 | pubmed:meshHeading | pubmed-meshheading:15265502... | lld:pubmed |
| pubmed-article:15265502 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15265502 | pubmed:articleTitle | A critical structural determinant of opioid receptor interaction with phenolic 5-phenylmorphans. | lld:pubmed |
| pubmed-article:15265502 | pubmed:affiliation | Laboratory of Medicinal Chemistry, Building 8, Room B1-23, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-0815, USA. | lld:pubmed |
| pubmed-article:15265502 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15265502 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15265502 | lld:pubmed |
