| pubmed-article:15256433 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15256433 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15256433 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:15256433 | lifeskim:mentions | umls-concept:C0151692 | lld:lifeskim |
| pubmed-article:15256433 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:15256433 | lifeskim:mentions | umls-concept:C0598934 | lld:lifeskim |
| pubmed-article:15256433 | lifeskim:mentions | umls-concept:C0136134 | lld:lifeskim |
| pubmed-article:15256433 | lifeskim:mentions | umls-concept:C2327880 | lld:lifeskim |
| pubmed-article:15256433 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:15256433 | pubmed:dateCreated | 2004-7-16 | lld:pubmed |
| pubmed-article:15256433 | pubmed:abstractText | Perlecan, a modular proteoglycan carrying primary heparan sulfate (HS) side chains, is a major component of blood vessel basement membranes. It sequesters growth factors such as fibroblast growth factor 2 (FGF-2) and regulates the ligand-receptor interactions on the cell surface, and thus it has been implicated in the control of angiogenesis. Both stimulatory and inhibitory effects of perlecan on FGF-2 signaling have been reported. To understand the in vivo function of HS carried by perlecan, the perlecan gene heparan sulfate proteoglycan 2 (Hspg2) was mutated in mouse by gene targeting. The HS at the NH(2) terminus of perlecan was removed while the core protein remained intact. Perlecan HS-deficient (Hspg2(Delta3/Delta3)) mice survived embryonic development and were apparently healthy as adults. However, mutant mice exhibited significantly delayed wound healing, retarded FGF-2-induced tumor growth, and defective angiogenesis. In the mouse corneal angiogenesis model, FGF-2-induced neovascularization was significantly impaired in Hspg2(Delta3/Delta3) mutant mice. Our results suggest that HS in perlecan positively regulates the angiogenesis in vivo. | lld:pubmed |
| pubmed-article:15256433 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15256433 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15256433 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15256433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15256433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15256433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15256433 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15256433 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15256433 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:15256433 | pubmed:author | pubmed-author:MoritaHiroyuk... | lld:pubmed |
| pubmed-article:15256433 | pubmed:author | pubmed-author:CaoRenhaiR | lld:pubmed |
| pubmed-article:15256433 | pubmed:author | pubmed-author:SoininenRaija... | lld:pubmed |
| pubmed-article:15256433 | pubmed:author | pubmed-author:CaoYihaiY | lld:pubmed |
| pubmed-article:15256433 | pubmed:author | pubmed-author:TryggvasonKar... | lld:pubmed |
| pubmed-article:15256433 | pubmed:author | pubmed-author:ZhouZhongjunZ | lld:pubmed |
| pubmed-article:15256433 | pubmed:author | pubmed-author:WangJianmingJ | lld:pubmed |
| pubmed-article:15256433 | pubmed:author | pubmed-author:LiuBaohuaB | lld:pubmed |
| pubmed-article:15256433 | pubmed:author | pubmed-author:ChanKui... | lld:pubmed |
| pubmed-article:15256433 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15256433 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15256433 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:15256433 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15256433 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15256433 | pubmed:pagination | 4699-702 | lld:pubmed |
| pubmed-article:15256433 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15256433 | pubmed:meshHeading | pubmed-meshheading:15256433... | lld:pubmed |
| pubmed-article:15256433 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15256433 | pubmed:articleTitle | Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice. | lld:pubmed |
| pubmed-article:15256433 | pubmed:affiliation | Department of Biochemistry, Faculty of Medicine, University of Hong Kong, 21 Sassoon Road, Hong Kong, ROC. zhongjun@hkucc.hku.hk | lld:pubmed |
| pubmed-article:15256433 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15256433 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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