pubmed-article:15249124 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:15249124 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:15249124 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
pubmed-article:15249124 | lifeskim:mentions | umls-concept:C0034843 | lld:lifeskim |
pubmed-article:15249124 | lifeskim:mentions | umls-concept:C1551336 | lld:lifeskim |
pubmed-article:15249124 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
pubmed-article:15249124 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
pubmed-article:15249124 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
pubmed-article:15249124 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
pubmed-article:15249124 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
pubmed-article:15249124 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
pubmed-article:15249124 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
pubmed-article:15249124 | pubmed:issue | 1-2 | lld:pubmed |
pubmed-article:15249124 | pubmed:dateCreated | 2004-7-13 | lld:pubmed |
pubmed-article:15249124 | pubmed:abstractText | Nuclear hormone receptors interact with the basal-transcriptional complex and/or coactivators to regulate transcriptional activation. These activator-target interactions recruit the transcriptional machinery to the promoter and may also stimulate transcriptional events subsequent to the binding of the machinery to the promoter or enhancer element. We describe a novel functional interaction of the nuclear thyroid receptor (TR), with a human Mediator component (hSrb7), and a human TFIIH component (hMo15). In mammalian two-hybrid experiments as well as in GST-pull down assays, hSrb7 interacts with TR but not with other nuclear receptors such as the retinoic acid receptor (RAR) or the vitamin D receptor (VDR). Whereas hMo15 also interacts with VDR and RAR in mammalian two-hybrid assays, no association of hSrb7 with VDR or RAR is found. Accordingly, cotransfection of TR and hSrb7 increases thyroid hormone (T3)-dependent transcription in an AF-2-dependent manner, while hSrb7 causes no stimulation of vitamin D- or retinoic acid-mediated transactivation. These results reveal a novel co-activator role for hSrb7 and hMo15 on TR transcriptional responses, and demonstrate that different receptors can selectively target different co-activators or general transcription factors to stimulate transcription. | lld:pubmed |
pubmed-article:15249124 | pubmed:language | eng | lld:pubmed |
pubmed-article:15249124 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15249124 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:15249124 | pubmed:month | Jul | lld:pubmed |
pubmed-article:15249124 | pubmed:issn | 0303-7207 | lld:pubmed |
pubmed-article:15249124 | pubmed:author | pubmed-author:ArandaAnaA | lld:pubmed |
pubmed-article:15249124 | pubmed:author | pubmed-author:TenbaumStepha... | lld:pubmed |
pubmed-article:15249124 | pubmed:author | pubmed-author:NevadoJuliánJ | lld:pubmed |
pubmed-article:15249124 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:15249124 | pubmed:day | 30 | lld:pubmed |
pubmed-article:15249124 | pubmed:volume | 222 | lld:pubmed |
pubmed-article:15249124 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:15249124 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:15249124 | pubmed:pagination | 41-51 | lld:pubmed |
pubmed-article:15249124 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:meshHeading | pubmed-meshheading:15249124... | lld:pubmed |
pubmed-article:15249124 | pubmed:year | 2004 | lld:pubmed |
pubmed-article:15249124 | pubmed:articleTitle | hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor. | lld:pubmed |
pubmed-article:15249124 | pubmed:affiliation | Unidad de Investigación, Hospital Universitario de Getafe, 28905 Getafe, Madrid, Spain. | lld:pubmed |
pubmed-article:15249124 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:15249124 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:1022 | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
entrez-gene:2959 | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
entrez-gene:7067 | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
entrez-gene:7421 | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
entrez-gene:8648 | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
entrez-gene:9412 | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
entrez-gene:5914 | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
entrez-gene:7068 | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15249124 | lld:entrezgene |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15249124 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15249124 | lld:pubmed |