Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15249124rdf:typepubmed:Citationlld:pubmed
pubmed-article:15249124lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:15249124lifeskim:mentionsumls-concept:C1179435lld:lifeskim
pubmed-article:15249124lifeskim:mentionsumls-concept:C0034843lld:lifeskim
pubmed-article:15249124lifeskim:mentionsumls-concept:C1551336lld:lifeskim
pubmed-article:15249124lifeskim:mentionsumls-concept:C1705248lld:lifeskim
pubmed-article:15249124lifeskim:mentionsumls-concept:C0205224lld:lifeskim
pubmed-article:15249124lifeskim:mentionsumls-concept:C1548799lld:lifeskim
pubmed-article:15249124lifeskim:mentionsumls-concept:C1524073lld:lifeskim
pubmed-article:15249124lifeskim:mentionsumls-concept:C0127400lld:lifeskim
pubmed-article:15249124lifeskim:mentionsumls-concept:C0449432lld:lifeskim
pubmed-article:15249124lifeskim:mentionsumls-concept:C1363844lld:lifeskim
pubmed-article:15249124pubmed:issue1-2lld:pubmed
pubmed-article:15249124pubmed:dateCreated2004-7-13lld:pubmed
pubmed-article:15249124pubmed:abstractTextNuclear hormone receptors interact with the basal-transcriptional complex and/or coactivators to regulate transcriptional activation. These activator-target interactions recruit the transcriptional machinery to the promoter and may also stimulate transcriptional events subsequent to the binding of the machinery to the promoter or enhancer element. We describe a novel functional interaction of the nuclear thyroid receptor (TR), with a human Mediator component (hSrb7), and a human TFIIH component (hMo15). In mammalian two-hybrid experiments as well as in GST-pull down assays, hSrb7 interacts with TR but not with other nuclear receptors such as the retinoic acid receptor (RAR) or the vitamin D receptor (VDR). Whereas hMo15 also interacts with VDR and RAR in mammalian two-hybrid assays, no association of hSrb7 with VDR or RAR is found. Accordingly, cotransfection of TR and hSrb7 increases thyroid hormone (T3)-dependent transcription in an AF-2-dependent manner, while hSrb7 causes no stimulation of vitamin D- or retinoic acid-mediated transactivation. These results reveal a novel co-activator role for hSrb7 and hMo15 on TR transcriptional responses, and demonstrate that different receptors can selectively target different co-activators or general transcription factors to stimulate transcription.lld:pubmed
pubmed-article:15249124pubmed:languageenglld:pubmed
pubmed-article:15249124pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:citationSubsetIMlld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15249124pubmed:statusMEDLINElld:pubmed
pubmed-article:15249124pubmed:monthJullld:pubmed
pubmed-article:15249124pubmed:issn0303-7207lld:pubmed
pubmed-article:15249124pubmed:authorpubmed-author:ArandaAnaAlld:pubmed
pubmed-article:15249124pubmed:authorpubmed-author:TenbaumStepha...lld:pubmed
pubmed-article:15249124pubmed:authorpubmed-author:NevadoJuliánJlld:pubmed
pubmed-article:15249124pubmed:issnTypePrintlld:pubmed
pubmed-article:15249124pubmed:day30lld:pubmed
pubmed-article:15249124pubmed:volume222lld:pubmed
pubmed-article:15249124pubmed:ownerNLMlld:pubmed
pubmed-article:15249124pubmed:authorsCompleteYlld:pubmed
pubmed-article:15249124pubmed:pagination41-51lld:pubmed
pubmed-article:15249124pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:meshHeadingpubmed-meshheading:15249124...lld:pubmed
pubmed-article:15249124pubmed:year2004lld:pubmed
pubmed-article:15249124pubmed:articleTitlehSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor.lld:pubmed
pubmed-article:15249124pubmed:affiliationUnidad de Investigación, Hospital Universitario de Getafe, 28905 Getafe, Madrid, Spain.lld:pubmed
pubmed-article:15249124pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15249124pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:1022entrezgene:pubmedpubmed-article:15249124lld:entrezgene
entrez-gene:2959entrezgene:pubmedpubmed-article:15249124lld:entrezgene
entrez-gene:7067entrezgene:pubmedpubmed-article:15249124lld:entrezgene
entrez-gene:7421entrezgene:pubmedpubmed-article:15249124lld:entrezgene
entrez-gene:8648entrezgene:pubmedpubmed-article:15249124lld:entrezgene
entrez-gene:9412entrezgene:pubmedpubmed-article:15249124lld:entrezgene
entrez-gene:5914entrezgene:pubmedpubmed-article:15249124lld:entrezgene
entrez-gene:7068entrezgene:pubmedpubmed-article:15249124lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15249124lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15249124lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15249124lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15249124lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15249124lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15249124lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15249124lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15249124lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15249124lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15249124lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15249124lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15249124lld:pubmed