| pubmed-article:15236041 | pubmed:abstractText | The effect of human atrial natriuretic peptide (hANP) on blood pressure (Bp) was evaluated in 11 patients who had elevated systoric Bp of over 150 mmHg during surgery. A bolus injection of 50 microg or 100 microg of hANP decreased Bp with an immediate response by 27.6 +/- 3.1 mmHg (P < 0.001) or 40.7 +/- 4.2 mmHg (P < 0.001), respectively, accompanying with tremendously increased urine output. Heart rate and PaO2 were not altered. Thus, a intravenous bolus injection of hANP is an useful therapeutic tool for the treatment of acutely elevated Bp during anesthesia. | lld:pubmed |
