| pubmed-article:15210743 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15210743 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:15210743 | lifeskim:mentions | umls-concept:C0021743 | lld:lifeskim |
| pubmed-article:15210743 | lifeskim:mentions | umls-concept:C0670896 | lld:lifeskim |
| pubmed-article:15210743 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15210743 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15210743 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15210743 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15210743 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:15210743 | lifeskim:mentions | umls-concept:C1514758 | lld:lifeskim |
| pubmed-article:15210743 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:15210743 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15210743 | pubmed:dateCreated | 2004-6-22 | lld:pubmed |
| pubmed-article:15210743 | pubmed:abstractText | TANK-binding kinase-1 (TBK1) and the inducible IkappaB kinase (IKK-i) have been shown recently to activate interferon (IFN) regulatory factor-3 (IRF3), the primary transcription factor regulating induction of type I IFNs. Here, we have compared the role and specificity of TBK1 in the type I IFN response to lipopolysaccharide (LPS), polyI:C, and viral challenge by examining IRF3 nuclear translocation, signal transducer and activator of transcription 1 phosphorylation, and induction of IFN-regulated genes. The LPS and polyI:C-induced IFN responses were abolished and delayed, respectively, in macrophages from mice with a targeted disruption of the TBK1 gene. When challenged with Sendai virus, the IFN response was normal in TBK1(-/-) macrophages, but defective in TBK1(-/-) embryonic fibroblasts. Although both TBK1 and IKK-i are expressed in macrophages, only TBK1 but not IKK-i was detected in embryonic fibroblasts by Northern blotting analysis. Furthermore, the IFN response in TBK1(-/-) embryonic fibroblasts can be restored by reconstitution with wild-type IKK-i but not a mutant IKK-i lacking kinase activity. Thus, our studies suggest that TBK1 plays an important role in the Toll-like receptor-mediated IFN response and is redundant with IKK-i in the response of certain cell types to viral infection. | lld:pubmed |
| pubmed-article:15210743 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15210743 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15210743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15210743 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15210743 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15210743 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:15210743 | pubmed:author | pubmed-author:ChengGenhongG | lld:pubmed |
| pubmed-article:15210743 | pubmed:author | pubmed-author:YehWen-ChenWC | lld:pubmed |
| pubmed-article:15210743 | pubmed:author | pubmed-author:ChowEdward... | lld:pubmed |
| pubmed-article:15210743 | pubmed:author | pubmed-author:PerryAndrea... | lld:pubmed |
| pubmed-article:15210743 | pubmed:author | pubmed-author:GoodnoughJuli... | lld:pubmed |
| pubmed-article:15210743 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15210743 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:15210743 | pubmed:volume | 199 | lld:pubmed |
| pubmed-article:15210743 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15210743 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15210743 | pubmed:pagination | 1651-8 | lld:pubmed |
| pubmed-article:15210743 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15210743 | pubmed:meshHeading | pubmed-meshheading:15210743... | lld:pubmed |
| pubmed-article:15210743 | pubmed:meshHeading | pubmed-meshheading:15210743... | lld:pubmed |
| pubmed-article:15210743 | pubmed:meshHeading | pubmed-meshheading:15210743... | lld:pubmed |
| pubmed-article:15210743 | pubmed:meshHeading | pubmed-meshheading:15210743... | lld:pubmed |
