| pubmed-article:15210741 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15210741 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15210741 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:15210741 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:15210741 | lifeskim:mentions | umls-concept:C1819457 | lld:lifeskim |
| pubmed-article:15210741 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:15210741 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:15210741 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:15210741 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15210741 | pubmed:dateCreated | 2004-6-22 | lld:pubmed |
| pubmed-article:15210741 | pubmed:abstractText | Classical studies have demonstrated that in vitro priming of naive CD4 T cells to become T helper (Th)2 cells is strikingly dependent on interleukin (IL)-4, whereas priming for interferon (IFN)gamma production is IL-12/IFNgamma-dependent. Therefore, it was quite surprising when we noted that priming of naive C57BL/6 CD4(+) cells to become IL-4 producers was substantially inhibited by the addition of anti-IFNgamma antibodies. This was true using immobilized anti-CD3 and anti-CD28 antibodies or soluble anti-CD3/anti-CD28 and antigen-presenting cells in the presence or absence of added IL-4. Priming of CD4 T cells from IFNgamma(-/-) C57BL/6 mice with immobilized anti-CD3 and anti-CD28 resulted in limited production of IL-4, even with the addition of 1,000 U/ml of IL-4. Titrating IFNgamma into such cultures showed a striking increase in the proportion of T cells that secreted IL-4 upon challenge; this effect was completely IL-4-dependent in that it was blocked with anti-IL-4 antibody. Thus, IFNgamma plays an unanticipated but substantial role in Th2 priming, although it is an important Th1 cytokine, and under certain circumstances a Th1 inducer. | lld:pubmed |
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| pubmed-article:15210741 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15210741 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15210741 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15210741 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15210741 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:15210741 | pubmed:author | pubmed-author:FoucrasGilles... | lld:pubmed |
| pubmed-article:15210741 | pubmed:author | pubmed-author:PaulWilliam... | lld:pubmed |
| pubmed-article:15210741 | pubmed:author | pubmed-author:BocekPetrPJr | lld:pubmed |
| pubmed-article:15210741 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15210741 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:15210741 | pubmed:volume | 199 | lld:pubmed |
| pubmed-article:15210741 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15210741 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15210741 | pubmed:pagination | 1619-30 | lld:pubmed |
| pubmed-article:15210741 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15210741 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15210741 | pubmed:articleTitle | Interferon gamma enhances both in vitro and in vivo priming of CD4+ T cells for IL-4 production. | lld:pubmed |
| pubmed-article:15210741 | pubmed:affiliation | Division of Allergy, LAboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6610 Rockledge Dr., Rm. 3060, Bethesda, MD 20892, USA. pbocek@niaid.nih.gov | lld:pubmed |
| pubmed-article:15210741 | pubmed:publicationType | Journal Article | lld:pubmed |
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