| pubmed-article:15207786 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15207786 | lifeskim:mentions | umls-concept:C0019163 | lld:lifeskim |
| pubmed-article:15207786 | lifeskim:mentions | umls-concept:C0086413 | lld:lifeskim |
| pubmed-article:15207786 | lifeskim:mentions | umls-concept:C0036638 | lld:lifeskim |
| pubmed-article:15207786 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15207786 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15207786 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15207786 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:15207786 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15207786 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15207786 | lifeskim:mentions | umls-concept:C0444669 | lld:lifeskim |
| pubmed-article:15207786 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15207786 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15207786 | pubmed:dateCreated | 2004-6-21 | lld:pubmed |
| pubmed-article:15207786 | pubmed:abstractText | By using the hepatitis B core (HBc) protein gene as a carrier, HIV-1 env V3 gene was inserted into the carrier gene, and the HIV gene was expressed inside a chimeric HIV-HBc particle (HIV-HBc), which was a unique candidate for induction of HIV-specific CTL activity. This was seen significantly in mice without the need of an adjuvant, because other responses specific for the HIV peptide such as T-cell proliferation and antibody production were not induced. However, when hemagglutinating virus of Japan (HVJ) protein was incorporated into an anionic liposome containing HIV peptide (HIV-HVJ-liposome) and was used as a booster immunization in HIV-HBc primed animals, the HIV-specific T-cell response and enhanced CTL activity were clearly induced in consecutively immunized animals. Furthermore, the HIV-specific humoral immune response was also induced and a neutralization activity was detected in the immune sera. Thus, when an HIV peptide antigen is expressed inside the virus like a particle of HBc, it can induce both cellular and humoral immunities when an HVJ-HIV-liposome, but not an HIV-liposome, is inoculated as the booster antigen. The HVJ-stimulated splenocytes secreted IL-18 and IL-12 to synergistically enhance the secretion of IFN-gamma in vitro. These findings suggest that the HVJ protein is effective at inducing the HIV-specific immunities, if used as part of a booster antigen in the consecutive immunization regimen. | lld:pubmed |
| pubmed-article:15207786 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15207786 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207786 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15207786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207786 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15207786 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15207786 | pubmed:issn | 1521-6616 | lld:pubmed |
| pubmed-article:15207786 | pubmed:author | pubmed-author:HondaMitsuoM | lld:pubmed |
| pubmed-article:15207786 | pubmed:author | pubmed-author:KanedaYasufum... | lld:pubmed |
| pubmed-article:15207786 | pubmed:author | pubmed-author:YamamotoNaoki... | lld:pubmed |
| pubmed-article:15207786 | pubmed:author | pubmed-author:TakedaSatoshi... | lld:pubmed |
| pubmed-article:15207786 | pubmed:author | pubmed-author:SomeyaKenjiK | lld:pubmed |
| pubmed-article:15207786 | pubmed:author | pubmed-author:ShiosakiKouic... | lld:pubmed |
| pubmed-article:15207786 | pubmed:author | pubmed-author:NakasatomiTet... | lld:pubmed |
| pubmed-article:15207786 | pubmed:author | pubmed-author:YoshizakiHito... | lld:pubmed |
| pubmed-article:15207786 | pubmed:author | pubmed-author:KonnoYusukeY | lld:pubmed |
| pubmed-article:15207786 | pubmed:author | pubmed-author:EdaYasuyukiY | lld:pubmed |
| pubmed-article:15207786 | pubmed:author | pubmed-author:KinoYouichiro... | lld:pubmed |
| pubmed-article:15207786 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15207786 | pubmed:volume | 112 | lld:pubmed |
| pubmed-article:15207786 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15207786 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15207786 | pubmed:pagination | 92-105 | lld:pubmed |
| pubmed-article:15207786 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15207786 | pubmed:meshHeading | pubmed-meshheading:15207786... | lld:pubmed |
| pubmed-article:15207786 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15207786 | pubmed:articleTitle | Hemagglutinating virus of Japan protein is efficient for induction of CD4+ T-cell response by a hepatitis B core particle-based HIV vaccine. | lld:pubmed |
| pubmed-article:15207786 | pubmed:affiliation | AIDS Research Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan. | lld:pubmed |
| pubmed-article:15207786 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15207786 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15207786 | lld:pubmed |
