| pubmed-article:15207421 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15207421 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:15207421 | lifeskim:mentions | umls-concept:C0039062 | lld:lifeskim |
| pubmed-article:15207421 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:15207421 | lifeskim:mentions | umls-concept:C0598501 | lld:lifeskim |
| pubmed-article:15207421 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:15207421 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:15207421 | lifeskim:mentions | umls-concept:C0033413 | lld:lifeskim |
| pubmed-article:15207421 | lifeskim:mentions | umls-concept:C1412050 | lld:lifeskim |
| pubmed-article:15207421 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:15207421 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:15207421 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:15207421 | pubmed:dateCreated | 2004-6-21 | lld:pubmed |
| pubmed-article:15207421 | pubmed:abstractText | One-hundred-thirty-tree patients with neuropathologically confirmed Alzheimer's disease (AD) were genotyped for the polymorphic regions in the apolipoprotein Eepsilon (APOE)and a new polymorphism in the promoter region of the alpha-1-antichymotrypsin (ACT) gene. The ACT TT genotype was associated with a longer survival of AD patients, and among patients with the APOE epsilon4 allele, this genotype increased the duration of the disease. The ACT TT genotype was also associated with a late age at onset of the disease and a delayed age at death in patients without the APOE epsilon4 allele. This latter group of patients also showed increased levels of synaptophysin from the mid-frontal (MF) cortex area. ACT appears to play complex, multiple roles on AD and to affect synaptic plasticity in the AD brain of patients without the allele APOE epsilon4 allele. | lld:pubmed |
| pubmed-article:15207421 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15207421 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207421 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15207421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207421 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207421 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15207421 | pubmed:issn | 0924-7947 | lld:pubmed |
| pubmed-article:15207421 | pubmed:author | pubmed-author:ThalL JLJ | lld:pubmed |
| pubmed-article:15207421 | pubmed:author | pubmed-author:LicastroFF | lld:pubmed |
| pubmed-article:15207421 | pubmed:author | pubmed-author:MasliahEE | lld:pubmed |
| pubmed-article:15207421 | pubmed:author | pubmed-author:ChiappelliMM | lld:pubmed |
| pubmed-article:15207421 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15207421 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15207421 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15207421 | pubmed:pagination | 243-51 | lld:pubmed |
| pubmed-article:15207421 | pubmed:dateRevised | 2009-11-3 | lld:pubmed |
| pubmed-article:15207421 | pubmed:meshHeading | pubmed-meshheading:15207421... | lld:pubmed |
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| pubmed-article:15207421 | pubmed:meshHeading | pubmed-meshheading:15207421... | lld:pubmed |
| pubmed-article:15207421 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15207421 | pubmed:articleTitle | alpha-1-Antichymotrypsin polymorphism in the gene promoter region affects survival and synapsis loss in Alzheimer's disease. | lld:pubmed |
| pubmed-article:15207421 | pubmed:affiliation | Department of Experimental Pathology, School of Medicine, University of Bologna, I-40126 Bologna, Italy. licastro@alma.unibo.it | lld:pubmed |
| pubmed-article:15207421 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15207421 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
